Behavioral Effects of Congenital Ventromedial Prefrontal Cortex Malformation
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Behavioral Effects of Congenital Ventromedial Prefrontal Cortex Malformation
| Title: | Behavioral Effects of Congenital Ventromedial Prefrontal Cortex Malformation |
| Author: |
Grafft, Amanda Hornaday; Joshi, Charuta; Chuang, Nathaniel A; Nopoulos, Peg; Anderson, Steven W; Boes, Aaron
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Boes, Aaron D., Amanda Hornaday Grafft, Charuta Joshi, Nathaniel A. Chuang, Peg Nopoulos, and Steven W. Anderson. 2011. Behavioral effects of congenital ventromedial prefrontal cortex malformation. BMC Neurology 11:151. |
| Full Text & Related Files: |
3265436.pdf (1.149Mb; PDF) 
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| Abstract: | Background: A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC. Case Presentation: B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance. Conclusions: The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process. |
| Published Version: | doi:10.1186/1471-2377-11-151 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265436/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288947 |
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