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dc.contributor.authorCorcoran, Ryan Bruce
dc.contributor.authorSettleman, Jeffrey
dc.contributor.authorEngelman, Jeffrey Adam
dc.date.accessioned2013-02-14T21:39:45Z
dc.date.issued2011
dc.identifier.citationCorcoran, Ryan B., Jeffrey Settleman, and Jeffrey A. Engelman. 2011. Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in braf mutant cancers. Oncotarget 2(4): 336-346.en_US
dc.identifier.issn1949-2553en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10303288
dc.description.abstractRecent clinical trials with selective inhibitors of the BRAF and MEK kinases have shown promising results in patients with tumors harboring BRAF V600 mutations. However, as has been observed previously with similarly successful targeted therapies, acquired resistance to these agents is an emerging problem that limits their clinical benefit. Several recent studies from our laboratory and others have investigated the causes of acquired resistance to BRAF and MEK inhibitors, and multiple resistance mechanisms have been identified. Here, we review these mechanisms and suggest that they can be broadly grouped into two main classes: ERK-dependent and ERK-independent. We also propose distinct therapeutic strategies that might be employed to overcome each class of acquired resistance.en_US
dc.language.isoen_USen_US
dc.publisherImpact Journals LLCen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248170/pdf/en_US
dash.licenseLAA
dc.titlePotential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalOncotargeten_US
dash.depositing.authorCorcoran, Ryan Bruce
dc.date.available2013-02-14T21:39:45Z
dc.identifier.doi10.18632/oncotarget.262
dash.contributor.affiliatedCorcoran, Ryan
dash.contributor.affiliatedEngelman, Jeffrey A


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