The Histone Methyltransferase Set7/9 Promotes Myoblast Differentiation and Myofibril Assembly

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The Histone Methyltransferase Set7/9 Promotes Myoblast Differentiation and Myofibril Assembly

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Title: The Histone Methyltransferase Set7/9 Promotes Myoblast Differentiation and Myofibril Assembly
Author: Tao, Yazhong; Huang, Zhan-Peng; Chen, Jianfu; Tang, Ru-Hang; Cao, Ru; Jin, Suk-Won; Neppl, Ronald; Zhang, Yi; Wang, Da-Zhi

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Citation: Tao, Yazhong, Ronald L. Neppl, Zhan-Peng Huang, Jianfu Chen, Ru-Hang Tang, Ru Cao, Yi Zhang, Suk-Won Jin, and Da-Zhi Wang. 2011. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. The Journal of Cell Biology 194(4): 551-565.
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Abstract: The molecular events that modulate chromatin structure during skeletal muscle differentiation are still poorly understood. We report in this paper that expression of the H3-K4 histone methyltransferase Set7 is increased when myoblasts differentiate into myotubes and is required for skeletal muscle development, expression of muscle contractile proteins, and myofibril assembly. Knockdown of Set7 or expression of a dominant-negative Set7 mutant impairs skeletal muscle differentiation, accompanied by a decrease in levels of histone monomethylation (H3-K4me1). Set7 directly interacts with MyoD to enhance expression of muscle differentiation genes. Expression of myocyte enhancer factor 2 and genes encoding contractile proteins is decreased in Set7 knockdown myocytes. Furthermore, we demonstrate that Set7 also activates muscle gene expression by precluding Suv39h1-mediated H3-K9 methylation on the promoters of myogenic differentiation genes. Together, our experiments define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation.
Published Version: doi://10.1083/jcb.201010090
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160588/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10304393
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