Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival

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Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival

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Title: Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
Author: Chen, Howard H.; Yuan, Hushan; Josephson, Lee; Sosnovik, David E.

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Citation: Chen, Howard H., Hushan Yuan, Lee Josephson, and David E. Sosnovik. 2012. Theranostic imaging of the kinases and proteases that modulate cell death and survival. Theranostics 2(2): 148-155.
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Abstract: Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These include PI3-kinase, AKT and caspase-3. Here we review the approaches used to date to perform molecular imaging of these important targets. We focus in particular on approaches that include the possibility of modulating the activity of these kinases and proteases in a theranostic approach.
Published Version: doi:10.7150/thno.4077
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296472/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10304414
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