A Screen for Germination Mutants in Saccharomyces cerevisiae

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A Screen for Germination Mutants in Saccharomyces cerevisiae

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Title: A Screen for Germination Mutants in Saccharomyces cerevisiae
Author: Kloimwieder, Anne; Winston, Fred Marshall

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Citation: Kloimwieder, Anne, and Fred Winston. 2011. A screen for germination mutants in Saccharomyces cerevisiae. G3 1(2): 143-149.
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Abstract: Spore germination in Saccharomyces cerevisiae is a process in which a quiescent cell begins to divide. During germination, the cell undergoes dramatic changes in cell wall and membrane composition, as well as in gene expression. To understand germination in greater detail, we screened the S. cerevisiae deletion set for germination mutants. Our results identified two genes, TRF4 and ERG6, that are required for normal germination on solid media. TRF4 is a member of the TRAMP complex that, together with the exosome, degrades RNA polymerase II transcripts. ERG6 encodes a key step in ergosterol biosynthesis. Taken together, these results demonstrate the complex nature of germination and two genes important in the process.
Published Version: doi:10.1534/g3.111.000323
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276131/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10304560
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