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dc.contributor.authorLebron-Milad, Kelimer
dc.contributor.authorMilad, Mohammed Ragib
dc.date.accessioned2013-02-22T15:27:04Z
dc.date.issued2012
dc.identifier.citationLebron-Milad, Kelimer, and Mohammed R Milad. 2012. Sex differences, gonadal hormones and the fear extinction network: Implications for anxiety disorders. Biology of Mood & Anxiety Disorders 2:3.en_US
dc.identifier.issn2045-5380en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10330322
dc.description.abstractConvergent data from rodents and human studies have led to the development of models describing the neural mechanisms of fear extinction. Key components of the now well-characterized fear extinction network include the amygdala, hippocampus, and medial prefrontal cortical regions. These models are fueling novel hypotheses that are currently being tested with much refined experimental tools to examine the interactions within this network. Lagging far behind, however, is the examination of sex differences in this network and how sex hormones influence the functional activity and reactivity of these brain regions in the context of fear inhibition. Indeed, there is a large body of literature suggesting that sex hormones, such as estrogen, do modulate neural plasticity within the fear extinction network, especially in the hippocampus. After a brief overview of the fear extinction network, we summarize what is currently known about sex differences in fear extinction and the influence of gonadal hormones on the fear extinction network. We then go on to propose possible mechanisms by which sex hormones, such as estrogen, may influence neural plasticity within the fear extinction network. We end with a discussion of how knowledge to be gained from developing this line of research may have significant ramifications towards the etiology, epidemiology and treatment of anxiety disorders.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/2045-5380-2-3en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384233/pdf/en_US
dash.licenseLAA
dc.subjectmenstrual cycleen_US
dc.subjectsex hormonesen_US
dc.subjectestrogenen_US
dc.subjectprogesteroneen_US
dc.subjectestrus cycleen_US
dc.subjectfear extinctionen_US
dc.subjectestrous cycleen_US
dc.titleSex Differences, Gonadal Hormones and the Fear Extinction Network: Implications for Anxiety Disordersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBiology of Mood & Anxiety Disordersen_US
dash.depositing.authorMilad, Mohammed Ragib
dc.date.available2013-02-22T15:27:04Z
dc.identifier.doi10.1186/2045-5380-2-3*
dash.contributor.affiliatedMilad, Mohammed R.


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