Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not So Different After All!

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Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not So Different After All!

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Title: Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not So Different After All!
Author: Sebastiani, Paola; Sun, Jenny X.; Solovieff, Nadia

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Citation: Sebastiani, Paola, Nadia Solovieff, and Jenny X. Sun. 2012. Naïve Bayesian classifier and genetic risk score for genetic risk prediction of a categorical trait: Not so different after all! Frontiers in Genetics 3:26.
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Abstract: One of the most popular modeling approaches to genetic risk prediction is to use a summary of risk alleles in the form of an unweighted or a weighted genetic risk score, with weights that relate to the odds for the phenotype in carriers of the individual alleles. Recent contributions have proposed the use of Bayesian classification rules using Naïve Bayes classifiers. We examine the relation between the two approaches for genetic risk prediction and show that the methods are mathematically related. In addition, we study the properties of the two approaches and describe how they can be generalized to include various models of inheritance.
Published Version: doi:10.3389/fgene.2012.00026
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289795/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10332596
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