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dc.contributor.authorCastillo, Melany
dc.contributor.authorHall, Jessica Ann
dc.contributor.authorCorrea-Medina, Mayrin
dc.contributor.authorUeta, Cintia
dc.contributor.authorWon Kang, Hye
dc.contributor.authorCohen, David E.
dc.contributor.authorBianco, Antonio C.
dc.date.accessioned2013-02-22T20:02:48Z
dc.date.issued2011
dc.identifier.citationCastillo, Melany, Jessica A. Hall, Mayrin Correa-Medina, Cintia Ueta, Hye Won Kang, David E. Cohen, and Antonio C. Bianco. 2011. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes 60(4): 1082-1089.en_US
dc.identifier.issn0012-1797en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10336904
dc.description.abstractObjective: Thyroid hormone accelerates energy expenditure; thus, hypothyroidism is intuitively associated with obesity. However, studies failed to establish such a connection. In brown adipose tissue (BAT), thyroid hormone activation via type 2 deiodinase (D2) is necessary for adaptive thermogenesis, such that mice lacking D2 (D2KO) exhibit an impaired thermogenic response to cold. Here we investigate whether the impaired thermogenesis of D2KO mice increases their susceptibility to obesity when placed on a high-fat diet. Research Design and Methods: To test this, D2KO mice were admitted to a comprehensive monitoring system acclimatized to room temperature (22\(^\circ\)C) or thermoneutrality (30\(^\circ\)C) and kept either on chow or high-fat diet for 60 days. Results: At 22\(^\circ\)C, D2KO mice preferentially oxidize fat, have a similar sensitivity to diet-induced obesity, and are supertolerant to glucose. However, when thermal stress is eliminated at thermoneutrality (30\(^\circ\)C), an opposite phenotype is encountered, one that includes obesity, glucose intolerance, and exacerbated hepatic steatosis. We suggest that a compensatory increase in BAT sympathetic activation of the D2KO mice masks metabolic repercussions that they would otherwise exhibit. Conclusions: Thus, upon minimization of thermal stress, high-fat feeding reveals the defective capacity of D2KO mice for diet-induced thermogenesis, provoking a paradigm shift in the understanding of the role of the thyroid hormone in metabolism.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi:10.2337/db10-0758en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064082/pdf/en_US
dash.licenseLAA
dc.titleDisruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutralityen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetesen_US
dash.depositing.authorCohen, David E.
dc.date.available2013-02-22T20:02:48Z
dc.identifier.doi10.2337/db10-0758*
dash.contributor.affiliatedHall, Jessica
dash.contributor.affiliatedCohen, David E.


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