Lymphatics and Lymphangiogenesis in the Eye

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Lymphatics and Lymphangiogenesis in the Eye

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dc.contributor.author Nakao, Shintaro
dc.contributor.author Ishibashi, Tatsuro
dc.contributor.author Hafezi-Moghadam, Ali
dc.date.accessioned 2013-02-25T18:46:51Z
dc.date.issued 2012
dc.identifier.citation Nakao, Shintaro, Ali Hafezi-Moghadam, and Tatsuro Ishibashi. 2012. Lymphatics and lymphangiogenesis in the eye. Journal of Ophthalmology 2012:783163. en_US
dc.identifier.issn 2090-004X en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:10344720
dc.description.abstract Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation. The eye was thought to lack lymphatic vessels except for the conjunctiva; however, advances in the field, including the identification of lymphatic endothelial markers (e.g., LYVE-1 or podoplanin) and lymphangiogenic factors (e.g., VEGF-C), have revealed the exsitence and possible roles of lymphatics and lymphangiogenesis in the eye. Recent studies have shown that corneal limbus, ciliary body, lacrimal gland, orbital meninges, and extraocular muscles contain lymphatic vessels and that the choroid might have a lymphatic-like system. There is no known lymphatic outflow from the eye. However, several lymphatic channels including uveolymphatic pathway might serve the ocular fluid homeostasis. Furthermore, lymphangiogenesis plays important roles in pathological conditions in the eye including corneal transplant rejection and ocular tumor progression. Yet, the role of lymphangiogenesis in most eye diseases, especially inflammatory disease or edema, remains unknown. A better understanding of lymphatic and lymphangiogenesis in the eye will open new therapeutic opportunities to prevent vision loss in ocular diseases. en_US
dc.language.iso en_US en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.isversionof doi:10.1155/2012/783163 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317234/pdf/ en_US
dash.license LAA
dc.title Lymphatics and Lymphangiogenesis in the Eye en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Ophthalmology en_US
dash.depositing.author Hafezi-Moghadam, Ali
dc.date.available 2013-02-25T18:46:51Z

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