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dc.contributor.authorNakao, Shintaro
dc.contributor.authorHafezi-Moghadam, Ali
dc.contributor.authorIshibashi, Tatsuro
dc.date.accessioned2013-02-25T18:46:51Z
dc.date.issued2012
dc.identifier.citationNakao, Shintaro, Ali Hafezi-Moghadam, and Tatsuro Ishibashi. 2012. Lymphatics and lymphangiogenesis in the eye. Journal of Ophthalmology 2012:783163.en_US
dc.identifier.issn2090-004Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10344720
dc.description.abstractLymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation. The eye was thought to lack lymphatic vessels except for the conjunctiva; however, advances in the field, including the identification of lymphatic endothelial markers (e.g., LYVE-1 or podoplanin) and lymphangiogenic factors (e.g., VEGF-C), have revealed the exsitence and possible roles of lymphatics and lymphangiogenesis in the eye. Recent studies have shown that corneal limbus, ciliary body, lacrimal gland, orbital meninges, and extraocular muscles contain lymphatic vessels and that the choroid might have a lymphatic-like system. There is no known lymphatic outflow from the eye. However, several lymphatic channels including uveolymphatic pathway might serve the ocular fluid homeostasis. Furthermore, lymphangiogenesis plays important roles in pathological conditions in the eye including corneal transplant rejection and ocular tumor progression. Yet, the role of lymphangiogenesis in most eye diseases, especially inflammatory disease or edema, remains unknown. A better understanding of lymphatic and lymphangiogenesis in the eye will open new therapeutic opportunities to prevent vision loss in ocular diseases.en_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofdoi:10.1155/2012/783163en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317234/pdf/en_US
dash.licenseLAA
dc.titleLymphatics and Lymphangiogenesis in the Eyeen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Ophthalmologyen_US
dash.depositing.authorHafezi-Moghadam, Ali
dc.date.available2013-02-25T18:46:51Z
dc.identifier.doi10.1155/2012/783163*
dash.contributor.affiliatedHafezi-Moghadam, Ali


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