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dc.contributor.authorLim, Soo
dc.contributor.authorShin, Hayley
dc.contributor.authorCho, Bong Jun
dc.contributor.authorAhn, Byung Yong
dc.contributor.authorKang, Seon Mee
dc.contributor.authorYoon, Ji Won
dc.contributor.authorJang, Hak Chul
dc.contributor.authorPark, Kyong Soo
dc.contributor.authorChoi, Sung Hee
dc.contributor.authorPark, Ho Seon
dc.contributor.authorKim, Young-Bum
dc.date.accessioned2013-02-26T16:19:22Z
dc.date.issued2012
dc.identifier.citationLim, Soo, Sung Hee Choi, Hayley Shin, Bong Jun Cho, Ho Seon Park, Byung Yong Ahn, Seon Mee Kang, et al. 2012. Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats. PLoS ONE 7(4): e35007.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10345113
dc.description.abstractBackground: Recently, it has been suggested that enhancement of incretin effect improves cardiac function. We investigated the effect of a DPP-IV inhibitor, des-fluoro-sitagliptin, in reducing occurrence of restenosis in carotid artery in response to balloon injury and the related mechanisms. Methods and Findings: Otsuka Long-Evans Tokushima Fatty rats were grouped into four: control (normal saline) and sitagliptin 100, 250 and 500 mg/kg per day (n = 10 per group). Sitagliptin or normal saline were given orally from 1 week before to 2 weeks after carotid injury. After 3 weeks of treatment, sitagliptin treatment caused a significant and dose-dependent reduction in intima-media ratio (IMR) in obese diabetic rats. This effect was accompanied by improved glucose homeostasis, decreased circulating levels of high-sensitivity C-reactive protein (hsCRP) and increased adiponectin level. Moreover, decreased IMR was correlated significantly with reduced hsCRP, tumor necrosis factor-\(\alpha\) and monocyte chemoattractant protein-1 levels and plasminogen activator inhibitor-1 activity. In vitro evidence with vascular smooth muscle cells (VSMCs) demonstrated that proliferation and migration were decreased significantly after sitagliptin treatment. In addition, sitagliptin increased caspase-3 activity and decreased monocyte adhesion and NFκB activation in VSMCs. Conclusions: Sitagliptin has protective properties against restenosis after carotid injury and therapeutic implications for treating macrovascular complications of diabetes.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0035007en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320861/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectBiochemistryen_US
dc.subjectDrug Discoveryen_US
dc.subjectBiotechnologyen_US
dc.subjectModel Organismsen_US
dc.subjectAnimal Modelsen_US
dc.subjectRaten_US
dc.subjectMedicineen_US
dc.subjectCardiovascularen_US
dc.subjectAtherosclerosisen_US
dc.subjectCardiovascular Pharmacologyen_US
dc.subjectVascular Biologyen_US
dc.subjectDrugs and Devicesen_US
dc.subjectDrug Research and Developmenten_US
dc.titleEffect of a Dipeptidyl Peptidase-IV Inhibitor, Des-Fluoro-Sitagliptin, on Neointimal Formation after Balloon Injury in Ratsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorKim, Young-Bum
dc.date.available2013-02-26T16:19:22Z
dc.identifier.doi10.1371/journal.pone.0035007*
dash.authorsorderedfalse
dash.contributor.affiliatedKim, Young-Bum
dash.contributor.affiliatedChoi, Sung Hee


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