Show simple item record

dc.contributor.authorSchwaber, Mitchell J.
dc.contributor.authorCosgrove, Sara E.
dc.contributor.authorGold, Howard Seth
dc.contributor.authorKaye, Keith S.
dc.contributor.authorCarmeli, Yehuda
dc.date.accessioned2013-02-26T20:27:41Z
dc.date.issued2004
dc.identifier.citationSchwaber, Mitchell J., Sara E. Cosgrove, Howard S. Gold, Keith S. Kaye, and Yehuda Carmeli. 2004. Fluoroquinolones protective against cephalosporin resistance in gram-negative nosocomial pathogens. Emerging Infectious Diseases 10(1): 94-99.en_US
dc.identifier.issn1080-6040en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10347166
dc.description.abstractIn a matched case-control study, we studied the effect of prior receipt of fluoroquinolones on isolation of three third-generation cephalosporin-resistant gram-negative nosocomial pathogens. Two hundred eighty-two cases with a third-generation cephalosporin-resistant pathogen (203 with Enterobacter spp., 50 with Pseudomonas aeruginosa, and 29 with Klebsiella pneumoniae) were matched on length of stay to controls in a 1:2 ratio. Case-patients and controls were similar in age (mean 62 years) and sex (54% male). Variables predicting third-generation cephalosporin resistance were surgery (p = 0.005); intensive care unit stay (p < 0.001); and receipt of a \(\beta\)-lactam/\(\beta\)-lactamase inhibitor (p < 0.001), a ureidopenicillin (p = 0.002), or a third-generation cephalosporin (p < 0.001). Receipt of a fluoroquinolone was protective against isolation of a third-generation cephalosporin-resistant pathogen (p = 0.005). Interventional studies are required to determine whether replacing third-generation cephalosporins with fluoroquinolones will be effective in reducing cephalosporin resistance and the effect of such interventions on fluoroquinolone resistance.en_US
dc.language.isoen_USen_US
dc.publisherCenters for Disease Control and Preventionen_US
dc.relation.isversionofdoi:10.3201/eid1001.020663en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322754/pdf/en_US
dash.licenseLAA
dc.titleFluoroquinolones Protective against Cephalosporin Resistance in Gram-Negative Nosocomial Pathogensen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEmerging Infectious Diseasesen_US
dash.depositing.authorGold, Howard Seth
dc.date.available2013-02-26T20:27:41Z
dc.identifier.doi10.3201/eid1001.020663*
dash.contributor.affiliatedGold, Howard
dash.contributor.affiliatedCarmeli, Yehuda


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record