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dc.contributor.authorWang, Rui
dc.contributor.authorStarkey, Melissa
dc.contributor.authorHazan, Ronen N.
dc.contributor.authorRahme, Laurence G.
dc.date.accessioned2013-02-26T20:59:11Z
dc.date.issued2012
dc.identifier.citationWang, Rui, Melissa Starkey, Ronen Hazan, and Laurence G. Rahme. 2012. Honey’s ability to counter bacterial infections arises from both bactericidal compounds and QS inhibition. Frontiers in Microbiology 3:144.en_US
dc.identifier.issn1664-302Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10347177
dc.description.abstractThe ability of honey to kill bacterial pathogens in vitro and quickly clear even chronic or drug-resistant infections has been demonstrated by several studies. Most current research is focused on identifying the bactericidal compounds in honey, but the action of the compounds discovered is not sufficient to explain honey’s activity. By diluting honey to sub-inhibitory levels, we were able to study its impact on bacterial coordinated behavior, and discovered that honey inhibits bacterial quorum sensing (QS). Experiments to characterize and quantify honey’s effect on the QS networks of Pseudomonas aeruginosa revealed that low concentrations of honey inhibited the expression of MvfR, las, and rhl regulons, including the associated virulence factors. This research also establishes that inhibition of QS is associated with honey’s sugar content. Therefore, honey combats infections by two independent mechanisms acting in tandem: bactericidal components, which actively kill cells, and disruption of QS, which weakens bacterial coordination and virulence.en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.isversionofdoi:10.3389/fmicb.2012.00144en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323871/pdf/en_US
dash.licenseLAA
dc.subjecthoneyen_US
dc.subjectPseudomonasen_US
dc.subjectquorum-sensingen_US
dc.subjectinfectionen_US
dc.subjectanti-infectiveen_US
dc.subjectQS inhibitionen_US
dc.subjectmvfR(pqsR)en_US
dc.subjectsugarsen_US
dc.titleHoney’s Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibitionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalFrontiers in Microbiologyen_US
dash.depositing.authorRahme, Laurence G.
dc.date.available2013-02-26T20:59:11Z
dc.identifier.doi10.3389/fmicb.2012.00144*
dash.contributor.affiliatedHazan, Ronen N.
dash.contributor.affiliatedRahme, Laurence
dash.contributor.affiliatedWang, Rui


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