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dc.contributor.authorZwemer, Lillian M
dc.contributor.authorZak, Alexander
dc.contributor.authorThompson, Benjamin R
dc.contributor.authorKirby, Andrew
dc.contributor.authorDaly, Mark Joseph
dc.contributor.authorChess, Andrew
dc.contributor.authorGimelbrant, Alexander
dc.date.accessioned2013-02-26T21:09:49Z
dc.date.issued2012
dc.identifier.citationZwemer, Lillian M., Alexander Zak, Benjamin R. Thompson, Andrew Kirby, Mark J. Daly, Andrew Chess, and Alexander A. Gimelbrant. 2012. Autosomal monoallelic expression in the mouse. Genome Biology 13(2): R10.en_US
dc.identifier.issn1465-6906en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10347179
dc.description.abstractBackground: Random monoallelic expression defines an unusual class of genes displaying random choice for expression between the maternal and paternal alleles. Once established, the allele-specific expression pattern is stably maintained and mitotically inherited. Examples of random monoallelic genes include those found on the X-chromosome and a subset of autosomal genes, which have been most extensively studied in humans. Here, we report a genome-wide analysis of random monoallelic expression in the mouse. We used high density mouse genome polymorphism mapping arrays to assess allele-specific expression in clonal cell lines derived from heterozygous mouse strains. Results: Over 1,300 autosomal genes were assessed for allele-specific expression, and greater than 10% of them showed random monoallelic expression. When comparing mouse and human, the number of autosomal orthologs demonstrating random monoallelic expression in both organisms was greater than would be expected by chance. Random monoallelic expression on the mouse autosomes is broadly similar to that in human cells: it is widespread throughout the genome, lacks chromosome-wide coordination, and varies between cell types. However, for some mouse genes, there appears to be skewing, in some ways resembling skewed X-inactivation, wherein one allele is more frequently active. Conclusions: These data suggest that autosomal random monoallelic expression was present at least as far back as the last common ancestor of rodents and primates. Random monoallelic expression can lead to phenotypic variation beyond the phenotypic variation dictated by genotypic variation. Thus, it is important to take into account random monoallelic expression when examining genotype-phenotype correlation.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/gb-2012-13-2-r10en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334567/pdf/en_US
dash.licenseLAA
dc.subjectallelesen_US
dc.subjectgeneticsen_US
dc.subjectallelic imbalanceen_US
dc.subjectanimalsen_US
dc.subjectchromosomesen_US
dc.subjectgene expressionen_US
dc.subjectgenetic association studiesen_US
dc.subjectgenomeen_US
dc.subjectgenotypeen_US
dc.subjecthumansen_US
dc.subjectmiceen_US
dc.subjectoligonucleotide array sequence analysisen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleAutosomal Monoallelic Expression in the Mouseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalGenome Biologyen_US
dash.depositing.authorGimelbrant, Alexander
dc.date.available2013-02-26T21:09:49Z
dc.identifier.doi10.1186/gb-2012-13-2-r10*
dash.contributor.affiliatedGimelbrant, Alexander
dash.contributor.affiliatedDaly, Mark


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