The Microenvironment in Breast Cancer Progression: Biology and Implications for Treatment

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The Microenvironment in Breast Cancer Progression: Biology and Implications for Treatment

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Title: The Microenvironment in Breast Cancer Progression: Biology and Implications for Treatment
Author: Place, Andrew Elliott; Polyak, Kornelia; Huh, Sung Jin

Note: Order does not necessarily reflect citation order of authors.

Citation: Place, Andrew E., Sung Jin Huh, and Kornelia Polyak. 2011. The microenvironment in breast cancer progression: Biology and implications for treatment. Breast Cancer Research 13(6): 227.
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Abstract: Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized as a critical participant in tumor progression and therapeutic responses. Recent data demonstrate significant gene expression and epigenetic alterations in cells composing the microenvironment during disease progression, which can be explored as biomarkers and targets for therapy. Indeed, gene expression signatures derived from tumor stroma have been linked to clinical outcomes. There is increasing interest in translating our current understanding of the tumor microenvironment to the development of novel therapies.
Published Version: doi:10.1186/bcr2912
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326543/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10361971
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