dc.contributor.author | Yan, Chunguang | |
dc.contributor.author | Wang, Ximo | |
dc.contributor.author | Cao, Jay | |
dc.contributor.author | Wu, Min | |
dc.contributor.author | Gao, Hongwei | |
dc.date.accessioned | 2013-03-04T19:06:33Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Yan, Chunguang, Ximo Wang, Jay Cao, Min Wu, and Hongwei Gao. 2012. CCAAT/enhancer-binding protein \(\gamma\) is a critical regulator of IL-1\(\beta\)-induced IL-6 production in alveolar epithelial cells. PLoS ONE 7(4): e35492. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10362024 | |
dc.description.abstract | CCAAT/enhancer binding protein \(\gamma\) (C/EBPγ) is a member of the C/EBP family of transcription factors, which lacks known activation domains. C/EBP\(\gamma\) was originally described as an inhibitor of C/EBP transactivation potential. However, previous study demonstrates that C/EBP\(\gamma\) augments the C/EBP\(\beta\) stimulatory activity in lipopolysaccharide induction of IL-6 promoter in a B lymphoblast cell line. These data indicate a complexing functional role for C/EBP\(\gamma\) in regulating gene expression. Furthermore, the expression and function of C/EBP\(\gamma\) during inflammation are still largely unknown. In this study, we demonstrate that C/EBP\(\gamma\) activation was induced by IL-1\(\beta\) treatment in lung epithelial cells. Importantly, we demonstrate for the first time that C/EBP\(\gamma\) plays a critical role in regulating IL-1\(\beta\)-induced IL-6 expression in both mouse primary alveolar type II epithelial cells and a lung epithelial cell line, MLE12. We further provide the evidence that C/EBP\(\gamma\) inhibits IL-6 expression by inhibiting C/EBP\(\beta\) but not NF-\(\kappa\)B stimulatory activity in MLE12 cells. These findings suggest that C/EBP\(\gamma\) is a key transcription factor that regulates the IL-6 expression in alveolar epithelial cells, and may play an important regulatory role in lung inflammatory responses. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0035492 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338717/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Biology | en_US |
dc.subject | Biochemistry | en_US |
dc.subject | Proteins | en_US |
dc.subject | DNA-binding proteins | en_US |
dc.subject | Immunology | en_US |
dc.subject | Immunity | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Molecular Cell Biology | en_US |
dc.subject | Gene Expression | en_US |
dc.subject | Medicine | en_US |
dc.subject | Clinical Immunology | en_US |
dc.subject | Critical Care and Emergency Medicine | en_US |
dc.subject | Respiratory Failure | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Pulmonology | en_US |
dc.subject | Chronic Obstructive Pulmonary Diseases | en_US |
dc.subject | Interstitial Lung Diseases | en_US |
dc.subject | Pediatric Pulmonology | en_US |
dc.subject | Pleural Diseases | en_US |
dc.subject | Respiratory Infections | en_US |
dc.subject | Smoking Related Disorders | en_US |
dc.title | CCAAT/Enhancer-Binding Protein \(\gamma\) Is a Critical Regulator of IL-1\(\beta\)-Induced IL-6 Production in Alveolar Epithelial Cells | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Gao, Hongwei | |
dc.date.available | 2013-03-04T19:06:33Z | |
dc.identifier.doi | 10.1371/journal.pone.0035492 | * |
dash.contributor.affiliated | Gao, Hongwei | |