Show simple item record

dc.contributor.authorTian, Bozhi
dc.contributor.authorLiu, Jia
dc.contributor.authorDvir, Tal
dc.contributor.authorJin, Lihua
dc.contributor.authorTsui, Jonathan H.
dc.contributor.authorQing, Quan
dc.contributor.authorSuo, Zhigang
dc.contributor.authorLanger, Robert S.
dc.contributor.authorKohane, Daniel Solomon
dc.contributor.authorLieber, Charles M.
dc.date.accessioned2013-03-05T16:13:57Z
dc.date.issued2012
dc.identifier.citationTian, Bozhi, Jia Liu, Tal Dvir, Lihua Jin, Jonathan H. Tsui, Quan Qing, Zhigang Suo, Robert S. Langer, Daniel Solomon Kohane, and Charles M. Lieber. 2012. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nature Materials 11(11): 986–994.en_US
dc.identifier.issn1476-1122en_US
dc.identifier.issn1476-4660en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10364595
dc.description.abstractThe development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological microenvironments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Furthermore, we show the integrated sensory capability of the nanoES by real-time monitoring of the local electrical activity within 3D nanoES/cardiomyocyte constructs, the response of 3D-nanoES-based neural and cardiac tissue models to drugs, and distinct pH changes inside and outside tubular vascular smooth muscle constructs.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/nmat3404en_US
dc.relation.hasversionhttp://europepmc.org/abstract/MED/22922448en_US
dash.licenseLAA
dc.subjectgene ontologyen_US
dc.subjectdiseasesen_US
dc.subjectchemicalsen_US
dc.titleMacroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissuesen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNature Materialsen_US
dash.depositing.authorLieber, Charles M.
dash.waiver2012-07-19
dc.date.available2013-03-05T16:13:57Z
dc.identifier.doi10.1038/nmat3404*
dash.contributor.affiliatedJin, Lihua
dash.contributor.affiliatedLiu, Jia
dash.contributor.affiliatedKohane, Daniel
dash.contributor.affiliatedSuo, Zhigang
dash.contributor.affiliatedLieber, Charles
dash.contributor.affiliatedLanger, Robert
dc.identifier.orcid0000-0002-4068-4844


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record