TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling

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TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling

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Title: TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling
Author: Shin, Yongdae; Lang, Matthew J.; Kim, Sun Taek; Brazin, Kristine N.; Mallis, Robert J.; Sun, Zhen-Yu Jim; Wagner, Gerhard; Reinherz, Ellis Leonard

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Citation: Kim, Sun Taek, Yongdae Shin, Kristine Brazin, Robert J. Mallis, Zhen-Yu J. Sun, Gerhard Wagner, Matthew J. Lang, and Ellis L. Reinherz. 2012. TCR mechanobiology: Torques and tunable structures linked to early T cell signaling. Frontiers in Immunology 3:76.
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Abstract: Mechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into biochemical signals upon specific peptide-MHC complex (pMHC) ligation. Tangential force applied along the pseudo-twofold symmetry axis of the TCR complex post-ligation results in the \(\alpha\beta\) heterodimer exerting torque on the CD3 heterodimers as a consequence of molecular movement at the T cell–APC interface. Accompanying TCR quaternary change likely fosters signaling via the lipid bilayer predicated on the magnitude and direction of the TCR–pMHC force. TCR glycans may modulate quaternary change, thereby altering signaling outcome as might the redox state of the CxxC motifs located proximal to the TM segments in the heterodimeric CD3 subunits. Predicted alterations in TCR TM segments and surrounding lipid will convert ectodomain ligation into the earliest intracellular signaling events.
Published Version: doi:10.3389/fimmu.2012.00076
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342345/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10368125
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