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dc.contributor.authorKim, Sun Taek
dc.contributor.authorSun, Zhen-Yu Jim
dc.contributor.authorShin, Yongdae
dc.contributor.authorBrazin, Kristine N.
dc.contributor.authorMallis, Robert J.
dc.contributor.authorWagner, Gerhard
dc.contributor.authorLang, Matthew J.
dc.contributor.authorReinherz, Ellis Leonard
dc.date.accessioned2013-03-05T21:50:04Z
dc.date.issued2012
dc.identifier.citationKim, Sun Taek, Yongdae Shin, Kristine Brazin, Robert J. Mallis, Zhen-Yu J. Sun, Gerhard Wagner, Matthew J. Lang, and Ellis L. Reinherz. 2012. TCR mechanobiology: Torques and tunable structures linked to early T cell signaling. Frontiers in Immunology 3:76.en_US
dc.identifier.issn1664-3224en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10368125
dc.description.abstractMechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into biochemical signals upon specific peptide-MHC complex (pMHC) ligation. Tangential force applied along the pseudo-twofold symmetry axis of the TCR complex post-ligation results in the \(\alpha\beta\) heterodimer exerting torque on the CD3 heterodimers as a consequence of molecular movement at the T cell–APC interface. Accompanying TCR quaternary change likely fosters signaling via the lipid bilayer predicated on the magnitude and direction of the TCR–pMHC force. TCR glycans may modulate quaternary change, thereby altering signaling outcome as might the redox state of the CxxC motifs located proximal to the TM segments in the heterodimeric CD3 subunits. Predicted alterations in TCR TM segments and surrounding lipid will convert ectodomain ligation into the earliest intracellular signaling events.en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.isversionofdoi:10.3389/fimmu.2012.00076en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342345/pdf/en_US
dash.licenseLAA
dc.subjectquaternary changeen_US
dc.subjectmechanosensoren_US
dc.subjectT cell signalingen_US
dc.subjectforce transductionen_US
dc.subjectantigen recognitionen_US
dc.titleTCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signalingen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalFrontiers in Immunologyen_US
dash.depositing.authorWagner, Gerhard
dc.date.available2013-03-05T21:50:04Z
dc.identifier.doi10.3389/fimmu.2012.00076*
dash.contributor.affiliatedMallis, Robert
dash.contributor.affiliatedBrazin, Kristine
dash.contributor.affiliatedReinherz, Ellis
dash.contributor.affiliatedSun, Zhen-Yu
dash.contributor.affiliatedWagner, Gerhard


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