YY1 Regulates Melanocyte Development and Function by Cooperating with MITF
Bell, Robert J. A.
Love, Kevin T.
Song, Jun S.
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CitationLi, Juying, Jun S. Song, Robert J. A. Bell, Thanh-Nga T. Tran, Rizwan Haq, Huifei Liu, Kevin T. Love, et al. 2012. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genetics 8(5): e1002688.
AbstractStudies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed profound melanocyte deficiency and premature gray hair, similar to the loss of melanocytes in human piebaldism and Waardenburg syndrome. Although YY1 is a ubiquitous transcription factor, YY1 interacts with M-MITF, the Waardenburg Syndrome IIA gene and a master transcriptional regulator of melanocytes. YY1 cooperates with M-MITF in regulating the expression of piebaldism gene KIT and multiple additional pigmentation genes. Moreover, ChIP–seq identified genome-wide YY1 targets in the melanocyte lineage. These studies mechanistically link genes implicated in human conditions of melanocyte deficiency and reveal how a ubiquitous factor (YY1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (M-MITF)—a general mechanism which may confer tissue-specific gene expression in multiple lineages.
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