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dc.contributor.authorLi, Juying
dc.contributor.authorBell, Robert J. A.
dc.contributor.authorLiu, Huifei
dc.contributor.authorLove, Kevin T.
dc.contributor.authorLarue, Lionel
dc.contributor.authorSong, Jun S.
dc.contributor.authorTran, Thanh-Nga Trinh
dc.contributor.authorHaq, Rizwan
dc.contributor.authorLanger, Robert S.
dc.contributor.authorAnderson, Daniel Griffith
dc.contributor.authorFisher, David Erich
dc.date.accessioned2013-03-06T20:28:12Z
dc.date.issued2012
dc.identifier.citationLi, Juying, Jun S. Song, Robert J. A. Bell, Thanh-Nga T. Tran, Rizwan Haq, Huifei Liu, Kevin T. Love, et al. 2012. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genetics 8(5): e1002688.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10370548
dc.description.abstractStudies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed profound melanocyte deficiency and premature gray hair, similar to the loss of melanocytes in human piebaldism and Waardenburg syndrome. Although YY1 is a ubiquitous transcription factor, YY1 interacts with M-MITF, the Waardenburg Syndrome IIA gene and a master transcriptional regulator of melanocytes. YY1 cooperates with M-MITF in regulating the expression of piebaldism gene KIT and multiple additional pigmentation genes. Moreover, ChIP–seq identified genome-wide YY1 targets in the melanocyte lineage. These studies mechanistically link genes implicated in human conditions of melanocyte deficiency and reveal how a ubiquitous factor (YY1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (M-MITF)—a general mechanism which may confer tissue-specific gene expression in multiple lineages.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1002688en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342948/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectDevelopmental Biologyen_US
dc.subjectGeneticsen_US
dc.titleYY1 Regulates Melanocyte Development and Function by Cooperating with MITFen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorFisher, David Erich
dc.date.available2013-03-06T20:28:12Z
dc.identifier.doi10.1371/journal.pgen.1002688*
dash.authorsorderedfalse
dash.contributor.affiliatedHaq, Rizwan
dash.contributor.affiliatedTran, Thanh-Nga
dash.contributor.affiliatedFisher, David
dash.contributor.affiliatedLanger, Robert
dash.contributor.affiliatedAnderson, Daniel


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