dc.contributor.author | Li, Juying | |
dc.contributor.author | Bell, Robert J. A. | |
dc.contributor.author | Liu, Huifei | |
dc.contributor.author | Love, Kevin T. | |
dc.contributor.author | Larue, Lionel | |
dc.contributor.author | Song, Jun S. | |
dc.contributor.author | Tran, Thanh-Nga Trinh | |
dc.contributor.author | Haq, Rizwan | |
dc.contributor.author | Langer, Robert S. | |
dc.contributor.author | Anderson, Daniel Griffith | |
dc.contributor.author | Fisher, David Erich | |
dc.date.accessioned | 2013-03-06T20:28:12Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Li, Juying, Jun S. Song, Robert J. A. Bell, Thanh-Nga T. Tran, Rizwan Haq, Huifei Liu, Kevin T. Love, et al. 2012. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genetics 8(5): e1002688. | en_US |
dc.identifier.issn | 1553-7390 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10370548 | |
dc.description.abstract | Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed profound melanocyte deficiency and premature gray hair, similar to the loss of melanocytes in human piebaldism and Waardenburg syndrome. Although YY1 is a ubiquitous transcription factor, YY1 interacts with M-MITF, the Waardenburg Syndrome IIA gene and a master transcriptional regulator of melanocytes. YY1 cooperates with M-MITF in regulating the expression of piebaldism gene KIT and multiple additional pigmentation genes. Moreover, ChIP–seq identified genome-wide YY1 targets in the melanocyte lineage. These studies mechanistically link genes implicated in human conditions of melanocyte deficiency and reveal how a ubiquitous factor (YY1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (M-MITF)—a general mechanism which may confer tissue-specific gene expression in multiple lineages. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pgen.1002688 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342948/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Biology | en_US |
dc.subject | Developmental Biology | en_US |
dc.subject | Genetics | en_US |
dc.title | YY1 Regulates Melanocyte Development and Function by Cooperating with MITF | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS Genetics | en_US |
dash.depositing.author | Fisher, David Erich | |
dc.date.available | 2013-03-06T20:28:12Z | |
dc.identifier.doi | 10.1371/journal.pgen.1002688 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Tran, Thanh-Nga | |
dash.contributor.affiliated | Fisher, David | |
dash.contributor.affiliated | Anderson, Daniel | |
dash.contributor.affiliated | Langer, Robert | |
dash.contributor.affiliated | Haq, Rizwan | |