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dc.contributor.authorFang, Shona C.
dc.contributor.authorMehta, Amar Jayant
dc.contributor.authorAlexeeff, Stacey E.
dc.contributor.authorGryparis, Alexandros
dc.contributor.authorCoull, Brent Andrew
dc.contributor.authorVokonas, Pantel S.
dc.contributor.authorChristiani, David C.
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2013-03-07T15:52:21Z
dc.date.issued2012
dc.identifier.citationFang, Shona C., Amar J. Mehta, Stacey E. Alexeeff, Alexandros Gryparis, Brent Coull, Pantel Vokonas, David C. Christiani, and Joel Schwartz. 2012. Residential black carbon exposure and circulating markers of systemic inflammation in elderly males: The normative aging study. Environmental Health Perspectives 120(5): 674-680.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10374960
dc.description.abstractBackground: Traffic-related particles (TRPs) are associated with adverse cardiovascular events. The exact mechanisms are unclear, but systemic inflammatory responses likely play a role. Objectives: We conducted a repeated measures study among male participants of the Normative Aging Study in the greater Boston, Massachusetts, area to determine whether individual-level residential black carbon (BC), a marker of TRPs, is associated with systemic inflammation and whether coronary heart disease (CHD), diabetes, and obesity modify associations. Methods: We quantified markers of inflammation in 1,163 serum samples from 580 men. Exposure to BC up to 4 weeks prior was predicted from a validated spatiotemporal land-use regression model. Linear mixed effects models estimated the effects of BC on each marker while adjusting for potential confounders. Results: Associations between BC and blood markers were not observed in main effects models or when stratified by obesity status. However, BC was positively associated with markers of inflammation in men with CHD (particularly vascular endothelial growth factor) and in men with diabetes (particularly interleukin-1\(\beta\) and tumor necrosis factor-\(\alpha\)). Significant exposure time windows varied by marker, although in general the strongest associations were observed with moving averages of 2–7 days after a lag of several days. Conclusions: In an elderly male population, estimated BC exposures were positively associated with markers of systemic inflammation but only in men with CHD or diabetes.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.1103982en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346771/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectblack carbonen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcoronary heart diseaseen_US
dc.subjectdiabetesen_US
dc.subjectinflammationen_US
dc.subjectland-use regression modelen_US
dc.subjectparticulate matteren_US
dc.subjectsusceptibleen_US
dc.subjecttrafficen_US
dc.titleResidential Black Carbon Exposure and Circulating Markers of Systemic Inflammation in Elderly Males: The Normative Aging Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorCoull, Brent Andrew
dc.date.available2013-03-07T15:52:21Z
dc.identifier.doi10.1289/ehp.1103982*
dash.contributor.affiliatedFang, Shona C
dash.contributor.affiliatedVokonas, Pantel
dash.contributor.affiliatedMehta, A
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedCoull, Brent
dash.contributor.affiliatedChristiani, David
dc.identifier.orcid0000-0002-2557-150X


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