IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor

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IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor

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Title: IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor
Author: Ayalon, Rivka; Beck, Laurence H.; Khosroshahi, Arezou; Salant, David J.; Bloch, Donald Bendit; Stone, John H.

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Citation: Khosroshahi, Arezou, Rivka Ayalon, Laurence H. Beck, David J. Salant, Donald B. Bloch, and John H. Stone. 2012. IgG4-related disease is not associated with antibody to the phospholipase A2 receptor. International Journal of Rheumatology 2012:139409.
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Abstract: Patients with IgG4-related disease (IgG4-RD) share histopathological characteristics that are similar across affected organs. The finding of infiltration with IgG4+ plasma cells in the proper clinical and histopathological contexts connects a large number of clinical entities that were viewed previously as separate conditions. The renal involvement in IgG4-RD is usually characterized by tubulointerstitial nephritis, but membranous nephropathy has also been reported to be one of the renal complications of IgG4-RD. The recent discovery that a high proportion of patients with idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies to the M-type phospholipase A2 receptor (PLA2R) in the circulation and glomerular immune deposits, together with the profound IgG4 hypergammaglobulinemia and occasional reports of membranous nephropathy in IgG4-RD, raised the question of a common antigen. To assess the presence of anti-PLA2R antibody in patients with IgG4-RD, we screened sera from 28 IgG4-RD patients by immunoblot. None of the patients in this cohort had detectable circulating anti-PLA2R antibodies. This study suggests that despite some clinical and serological overlaps between IgG4-RD and IMN,anti-PLA2R antibodies do not play a role in the pathogenesis of IgG4-RD. Additional studies of IgG4-RD with evidence of membranous nephropathy are important to exclude any definite relationship.
Published Version: doi:10.1155/2012/139409
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357948/pdf/
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Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10386870
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