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dc.contributor.authorKhosroshahi, Arezou
dc.contributor.authorAyalon, Rivka
dc.contributor.authorBeck, Laurence H.
dc.contributor.authorSalant, David J.
dc.contributor.authorBloch, Donald Bendit
dc.contributor.authorStone, John H.
dc.date.accessioned2013-03-12T17:15:30Z
dc.date.issued2012
dc.identifier.citationKhosroshahi, Arezou, Rivka Ayalon, Laurence H. Beck, David J. Salant, Donald B. Bloch, and John H. Stone. 2012. IgG4-related disease is not associated with antibody to the phospholipase A2 receptor. International Journal of Rheumatology 2012:139409.en_US
dc.identifier.issn1687-9260en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10386870
dc.description.abstractPatients with IgG4-related disease (IgG4-RD) share histopathological characteristics that are similar across affected organs. The finding of infiltration with IgG4+ plasma cells in the proper clinical and histopathological contexts connects a large number of clinical entities that were viewed previously as separate conditions. The renal involvement in IgG4-RD is usually characterized by tubulointerstitial nephritis, but membranous nephropathy has also been reported to be one of the renal complications of IgG4-RD. The recent discovery that a high proportion of patients with idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies to the M-type phospholipase A2 receptor (PLA2R) in the circulation and glomerular immune deposits, together with the profound IgG4 hypergammaglobulinemia and occasional reports of membranous nephropathy in IgG4-RD, raised the question of a common antigen. To assess the presence of anti-PLA2R antibody in patients with IgG4-RD, we screened sera from 28 IgG4-RD patients by immunoblot. None of the patients in this cohort had detectable circulating anti-PLA2R antibodies. This study suggests that despite some clinical and serological overlaps between IgG4-RD and IMN,anti-PLA2R antibodies do not play a role in the pathogenesis of IgG4-RD. Additional studies of IgG4-RD with evidence of membranous nephropathy are important to exclude any definite relationship.en_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofdoi:10.1155/2012/139409en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357948/pdf/en_US
dash.licenseLAA
dc.titleIgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptoren_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalInternational Journal of Rheumatologyen_US
dash.depositing.authorBloch, Donald Bendit
dc.date.available2013-03-12T17:15:30Z
dc.identifier.doi10.1155/2012/139409*
dash.contributor.affiliatedKhosroshahi, Arezou
dash.contributor.affiliatedStone, John
dash.contributor.affiliatedBloch, Donald


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