# Nut Consumption and Risk of Atrial Fibrillation in the Physicians' Health Study

 Title: Nut Consumption and Risk of Atrial Fibrillation in the Physicians' Health Study Author: Djousse, Luc; Gaziano, John Michael; Khawaja, O. Note: Order does not necessarily reflect citation order of authors. Citation: Khawaja, O., J.M. Gaziano, and L. Djousse. 2012. Nut consumption and risk of atrial fibrillation in the Physicians' Health Study. Nutrition Journal 11:17. Full Text & Related Files: 3361489.pdf (243.5Kb; PDF) Abstract: Background: Atrial Fibrillation is highly prevalent in clinical practice affecting approximately 2.3 million people in USA and 4.5 million people in European Union. The aim of the study was to examine the association between nut consumption and incident atrial fibrillation. Methods: Prospective cohort of 21,054 male participants of Physicians' Health Study I. Nut consumption was estimated using food frequency questionnaire and incident atrial fibrillation was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of atrial fibrillation. Results: The average age was 54.6 $$\pm$$ 9.5 years (40.7-87.1). During a mean follow up of 20 years (median 24 years), 3,317 cases of atrial fibrillation occurred. The crude incidence rate was 7.6, 7.4, 8.2, 7.9, and 6.8 cases/1000 person-years for people reporting nut consumption of rarely/never, 1-3/month, 1/per week, 2-6/week, and $$\geq$$ 7/week, respectively. Multivariable adjusted hazard ratios (95% CI) for incident atrial fibrillation were 1.00 (ref), 1.00 (0.90-1.11), 1.09 (0.97-1.21), 1.07 (0.95-1.21), and 0.91 (0.70-1.17) for nut consumption from the lowest to the highest category of nut consumption (p for trend 0.26). No statistically significant association between nut consumption and atrial fibrillation was found when stratified by body mass index (BMI < 25 vs $$\geq$$ 25 kg/m2) or age (< 65 vs. $$\geq$$ 65 years). Conclusions: Our data did not show an association between nut consumption and incident atrial fibrillation among US male physicians. Published Version: doi:10.1186/1475-2891-11-17 Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361489/pdf/ Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10387010 Downloads of this work: