Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

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Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

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Title: Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
Author: Tong, Rong; Hemmati, Houman D.; Langer, Robert S.; Kohane, Daniel Solomon

Note: Order does not necessarily reflect citation order of authors.

Citation: Tong, Rong, Houman D. Hemmati, Robert Langer, and Daniel S. Kohane. 2012. Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. Journal of the American Chemical Society 134(21): 8848-8855.
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Abstract: We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer.
Published Version: doi:10.1021/ja211888a
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363369/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10387753
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