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dc.contributor.authorOmura, Daniel T.
dc.contributor.authorClark, Damon A.
dc.contributor.authorSamuel, Aravinthan DT
dc.contributor.authorHorvitz, H. Robert
dc.date.accessioned2013-03-14T14:40:24Z
dc.date.issued2012
dc.identifier.citationOmura, Daniel T., Damon A. Clark, Aravinthan D.T. Samuel, and H. Robert Horvitz. 2012. Dopamine signaling is essential for precise rates of locomotion by C. elegans. PLoS ONE 7(6): e38649.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10403688
dc.description.abstractDopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight dopaminergic neurons. Using an automated particle-tracking system for the analysis of C. elegans locomotion, we observed that individual wild-type animals made small adjustments to their speed to maintain constant rates of locomotion. By contrast, individual mutant animals defective in the synthesis of dopamine made larger adjustments to their speeds, resulting in large fluctuations in their rates of locomotion. Mutants defective in dopamine signaling also frequently exhibited both abnormally high and abnormally low average speeds. The ability to make small adjustments to speed was restored to these mutants by treatment with dopamine. These behaviors depended on the D2-like dopamine receptor DOP-3 and the G-protein subunit GOA-1. We suggest that C. elegans and other animals, including humans, might share mechanisms by which dopamine restricts motor activity levels and coordinates movement.en_US
dc.description.sponsorshipPhysicsen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0038649en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374838/pdf/en_US
dash.licenseLAA
dc.subjectbiologyen_US
dc.subjectanatomy and physiologyen_US
dc.subjectneurological systemen_US
dc.subjectmotor systemsen_US
dc.subjectneural pathwaysen_US
dc.subjectbiochemistryen_US
dc.subjectneurochemistryen_US
dc.subjectneurochemicalsen_US
dc.subjectdopamineen_US
dc.subjectgeneticsen_US
dc.subjectgenetic mutationen_US
dc.subjectmutagenesisen_US
dc.subjectheredityen_US
dc.subjectphenotypesen_US
dc.subjectmolecular geneticsen_US
dc.subjectgene identification and analysisen_US
dc.subjectgene regulationen_US
dc.subjectgenetics of diseaseen_US
dc.subjectmodel organismsen_US
dc.subjectanimal modelsen_US
dc.subjectCaenorhabditis elegansen_US
dc.subjectmolecular cell biologyen_US
dc.subjectsignal transductionen_US
dc.subjectmembrane receptor signalingen_US
dc.subjectneurotransmitter receptor signalingen_US
dc.subjectneuroscienceen_US
dc.subjectneuromodulationen_US
dc.subjectbehavioral neuroscienceen_US
dc.subjectmolecular neuroscienceen_US
dc.subjectneurotransmittersen_US
dc.subjectmedicineen_US
dc.subjectneurologyen_US
dc.titleDopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegansen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorSamuel, Aravinthan DT
dc.date.available2013-03-14T14:40:24Z
dc.identifier.doi10.1371/journal.pone.0038649*
dash.contributor.affiliatedSamuel, Aravinthan


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