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dc.contributor.authorCarneiro, Mauricio
dc.contributor.authorHartl, Daniel L.
dc.date.accessioned2013-03-14T14:44:46Z
dc.date.issued2010
dc.identifier.citationCarneiro, Mauricio, and Daniel L. Hartl. 2010. Adaptive landscapes and protein evolution. Proceedings of the National Academy of Sciences 107(1): 1747-1751.en_US
dc.identifier.issn1091-6490en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10403689
dc.description.abstractThe principles governing protein evolution under strong selection are important because of the recent history of evolved resistance to insecticides, antibiotics, and vaccines. One experimental approach focuses on studies of mutant proteins and all combinations of mutant sites that could possibly be intermediates in the evolutionary pathway to resistance. In organisms carrying each of the engineered proteins, a measure of protein function or a proxy for fitness is estimated. The correspondence between protein sequence and fitness is widely known as a fitness landscape or adaptive landscape. Here, we examine some empirical fitness landscapes and compare them with simulated landscapes in which the fitnesses are randomly assigned. We find that mutant sites in real proteins show significantly more additivity than those obtained from random simulations. The high degree of additivity is reflected in a summary statistic for adaptive landscapes known as the “roughness,” which for the actual proteins so far examined lies in the smallest 0.5% tail of random landscapes.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.isversionof10.1073/pnas.0906192106en_US
dash.licenseLAA
dc.subjectantibiotic resistanceen_US
dc.subjectfitness landscapeen_US
dc.subjectmolecular evolutionen_US
dc.titleAdaptive Landscapes and Protein Evolutionen_US
dc.typeJournal Articleen_US
dc.description.versionAuthor's Originalen_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorHartl, Daniel L.
dash.waiver2009-09-09
dc.date.available2013-03-14T14:44:46Z
dc.identifier.doi10.1073/pnas.0906192106*
dash.contributor.affiliatedHartl, Daniel


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