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dc.contributor.authorMindrinos, Michael N.
dc.contributor.authorSeok, Junhee
dc.contributor.authorCuschieri, Joseph
dc.contributor.authorCuenca, Alex G.
dc.contributor.authorHayden, Douglas L.
dc.contributor.authorHennessy, Laura
dc.contributor.authorMoore, Ernest E.
dc.contributor.authorMinei, Joseph P.
dc.contributor.authorBankey, Paul E.
dc.contributor.authorSperry, Jason
dc.contributor.authorNathens, Avery B.
dc.contributor.authorBilliar, Timothy R.
dc.contributor.authorBrownstein, Bernard H.
dc.contributor.authorMason, Philip H.
dc.contributor.authorBaker, Henry V.
dc.contributor.authorFinnerty, Celeste C.
dc.contributor.authorJeschke, Marc G.
dc.contributor.authorLópez, M. Cecilia
dc.contributor.authorKlein, Matthew B.
dc.contributor.authorGamelli, Richard L.
dc.contributor.authorGibran, Nicole S.
dc.contributor.authorArnoldo, Brett
dc.contributor.authorXu, Weihong
dc.contributor.authorZhang, Yuping
dc.contributor.authorCalvano, Steven E.
dc.contributor.authorMcDonald-Smith, Grace P.
dc.contributor.authorStorey, John D.
dc.contributor.authorMoldawer, Lyle L.
dc.contributor.authorHerndon, David N.
dc.contributor.authorLowry, Stephen F.
dc.contributor.authorMaier, Ronald V.
dc.contributor.authorDavis, Ronald W.
dc.contributor.authorXiao, Wenzhong
dc.contributor.authorGao, Hong
dc.contributor.authorJohnson, Jeffrey L.
dc.contributor.authorWest, Michael A.
dc.contributor.authorSchoenfeld, David Alan
dc.contributor.authorCobb, Joseph Perren
dc.contributor.authorWarren, H. Shaw
dc.contributor.authorTompkins, Ronald Gary
dc.date.accessioned2013-03-14T17:52:06Z
dc.date.issued2011
dc.identifier.citationXiao, Wenzhong, Michael N. Mindrinos, Junhee Seok, Joseph Cuschieri, Alex G. Cuenca, Hong Gao, Douglas L. Hayden, et al. 2011. A genomic storm in critically injured humans. The Journal of Experimental Medicine 208(13): 2581-2590.en_US
dc.identifier.issn0022-1007en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10405988
dc.description.abstractHuman survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy subjects receiving low-dose bacterial endotoxin, and show that these severe stresses produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected "genomic storm." In severe blunt trauma, the early leukocyte genomic response is consistent with simultaneously increased expression of genes involved in the systemic inflammatory, innate immune, and compensatory antiinflammatory responses, as well as in the suppression of genes involved in adaptive immunity. Furthermore, complications like nosocomial infections and organ failure are not associated with any genomic evidence of a second hit and differ only in the magnitude and duration of this genomic reprioritization. The similarities in gene expression patterns between different injuries reveal an apparently fundamental human response to severe inflammatory stress, with genomic signatures that are surprisingly far more common than different. Based on these transcriptional data, we propose a new paradigm for the human immunological response to severe injury.en_US
dc.language.isoen_USen_US
dc.publisherThe Rockefeller University Pressen_US
dc.relation.isversionofdoi:10.1084/jem.20111354en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244029/pdf/en_US
dash.licenseLAA
dc.titleA Genomic Storm in Critically Injured Humansen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe Journal of Experimental Medicineen_US
dash.depositing.authorSchoenfeld, David Alan
dc.date.available2013-03-14T17:52:06Z
dc.identifier.doi10.1084/jem.20111354*
dash.authorsorderedfalse
dash.contributor.affiliatedXiao, Wenzhong
dash.contributor.affiliatedWarren, H.
dash.contributor.affiliatedCobb, Joseph Perren
dash.contributor.affiliatedSchoenfeld, David
dash.contributor.affiliatedTompkins, Ronald


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