# Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease

 Title: Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease Author: Wilkinson, Kim; El-Khoury, Joseph B. Note: Order does not necessarily reflect citation order of authors. Citation: Wilkinson, Kim, and Joseph El Khoury. 2012. Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. International Journal of Alzheimer's Disease 2012:489456. Full Text & Related Files: 3362056.pdf (1.279Mb; PDF) Abstract: Alzheimer's disease (AD) is increasing in prevalence with the aging population. Deposition of amyloid-$$\beta$$ (A$$\beta$$) in the brain of AD patients is a hallmark of the disease and is associated with increased microglial numbers and activation state. The interaction of microglia with A$$\beta$$ appears to play a dichotomous role in AD pathogenesis. On one hand, microglia can phagocytose and clear A$$\beta$$, but binding of microglia to A$$\beta$$ also increases their ability to produce inflammatory cytokines, chemokines, and neurotoxic reactive oxygen species (ROS). Scavenger receptors, a group of evolutionally conserved proteins expressed on the surface of microglia act as receptors for A$$\beta$$. Of particular interest are SCARA-1 (scavenger receptor A-1), CD36, and RAGE (receptor for advanced glycation end products). SCARA-1 appears to be involved in the clearance of A$$\beta$$, while CD36 and RAGE are involved in activation of microglia by A$$\beta$$. In this review, we discuss the roles of various scavenger receptors in the interaction of microglia with A$$\beta$$ and propose that these receptors play complementary, nonredundant functions in the development of AD pathology. We also discuss potential therapeutic applications for these receptors in AD. Published Version: doi:10.1155/2012/489456 Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362056/pdf/ Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10406325 Downloads of this work: