Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
Hofmann, Sigrun R.
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CitationHofmann, Sigrun R., Angela Roesen-Wolff, Gabriele Hahn, and Christian M. Hedrich. 2012. Update: Cytokine dysregulation in chronic nonbacterial osteomyelitis (CNO). International Journal of Rheumatology 2012:310206.
AbstractChronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is a non-bacterial osteitis of yet unknown origin. Secondary to the absence of both high-titer autoantibodies and autoreactive T lymphocytes, and the association with other autoimmune diseases, it was recently reclassified as an autoinflammatory disorder of the musculoskeletal system. Since its etiology is largely unknown, the diagnosis is based on clinical criteria, and treatment is empiric and not always successful. In this paper, we summarize recent advances in the understanding of possible etiopathogenetic mechanisms in CNO.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10406333
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