dc.contributor.author | Nejat, Maryam | |
dc.contributor.author | Pickering, John W | |
dc.contributor.author | Devarajan, Prasad | |
dc.contributor.author | Bonventre, Joseph Vincent | |
dc.contributor.author | Edelstein, Charles L | |
dc.contributor.author | Walker, Robert J | |
dc.contributor.author | Endre, Zoltán H | |
dc.date.accessioned | 2013-03-15T16:09:54Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Nejat, Maryam, John W. Pickering, Prasad Devarajan, Joseph V. Bonventre, Charles L. Edelstein, Robert J. Walker, and Zoltán H. Endre. 2012. Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney International 81(12): 1254-1262. | en_US |
dc.identifier.issn | 0085-2538 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10416141 | |
dc.description.abstract | Pre-renal acute kidney injury (AKI) is assumed to represent a physiological response to underperfusion. Its diagnosis is retrospective after a transient rise in plasma creatinine, usually associated with evidence of altered tubular transport, particularly that of sodium. In order to test whether pre-renal AKI is reversible because injury is less severe than that of sustained AKI, we measured urinary biomarkers of injury (cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), \(\gamma\)-glutamyl transpeptidase, IL-18, and kidney injury molecule-1 (KIM-1)) at 0, 12, and 24 h following ICU admission. A total of 529 patients were stratified into groups having no AKI, AKI with recovery by 24 h, recovery by 48 h, or the composite of AKI greater than 48 h or dialysis. Pre-renal AKI was identified in 61 patients as acute injury with recovery within 48 h and a fractional sodium excretion <1%. Biomarker concentrations significantly and progressively increased with the duration of AKI. After restricting the AKI recovery within the 48 h cohort to pre-renal AKI, this increase remained significant. The median concentration of KIM-1, cystatin C, and IL-18 were significantly greater in pre-renal AKI compared with no-AKI, while NGAL and \(\gamma\)-glutamyl transpeptidase concentrations were not significant. The median concentration of at least one biomarker was increased in all but three patients with pre-renal AKI. Thus, the reason why some but not all biomarkers were increased requires further study. The results suggest that pre-renal AKI represents a milder form of injury. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | doi:10.1038/ki.2012.23 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365288/pdf/ | en_US |
dash.license | LAA | |
dc.subject | acute kidney injury | en_US |
dc.subject | acute renal failure | en_US |
dc.subject | creatinine | en_US |
dc.title | Some Biomarkers of Acute Kidney Injury Are Increased in Pre-Renal Acute Injury | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Kidney International | en_US |
dash.depositing.author | Bonventre, Joseph Vincent | |
dc.date.available | 2013-03-15T16:09:54Z | |
dc.identifier.doi | 10.1038/ki.2012.23 | * |
dash.contributor.affiliated | Bonventre, Joseph | |