Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin

 
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Carr, Gavin
Poulsen, Michael
Klassen, Jonathan L.
Hou, Yanpeng
Wyche, Thomas P.
Bugni, Tim S.
Currie, Cameron R.
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https://doi.org/10.1021/ol301043p
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Carr, Gavin, Michael Poulsen, Jonathan L. Klassen, Yanpeng Hou, Thomas P. Wyche, Tim S. Bugni, Cameron R. Currie, and Jon Clardy. 2012. Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin. Organic Letters 14(11): 2822-2825.
Abstract
Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental \(^1\)H and \(^{13}\)C NMR chemical shifts, we propose that vinylamycin’s structure be revised from 3 to 4.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365539/pdf/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:10417533

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