Multi-Scale Motility Amplitude Associated with Suicidal Thoughts in Major Depression

DSpace/Manakin Repository

Multi-Scale Motility Amplitude Associated with Suicidal Thoughts in Major Depression

Citable link to this page

 

 
Title: Multi-Scale Motility Amplitude Associated with Suicidal Thoughts in Major Depression
Author: Indic, Premananda; Maggini, Carlo; Amore, Mario; Meschi, Tiziana; Borghi, Loris; Murray, Greg; Baldessarini, Ross John; Salvatore, Paola

Note: Order does not necessarily reflect citation order of authors.

Citation: Indic, Premananda, Greg Murray, Carlo Maggini, Mario Amore, Tiziana Meschi, Loris Borghi, Ross J. Baldessarini, and Paola Salvatore. 2012. Multi-scale motility amplitude associated with suicidal thoughts in major depression. PLoS ONE 7(6): e38761.
Full Text & Related Files:
Abstract: Major depression occurs at high prevalence in the general population, often starts in juvenile years, recurs over a lifetime, and is strongly associated with disability and suicide. Searches for biological markers in depression may have been hindered by assuming that depression is a unitary and relatively homogeneous disorder, mainly of mood, rather than addressing particular, clinically crucial features or diagnostic subtypes. Many studies have implicated quantitative alterations of motility rhythms in depressed human subjects. Since a candidate feature of great public-health significance is the unusually high risk of suicidal behavior in depressive disorders, we studied correlations between a measure (vulnerability index [VI]) derived from multi-scale characteristics of daily-motility rhythms in depressed subjects (n = 36) monitored with noninvasive, wrist-worn, electronic actigraphs and their self-assessed level of suicidal thinking operationalized as a wish to die. Patient-subjects had a stable clinical diagnosis of bipolar-I, bipolar-II, or unipolar major depression (n = 12 of each type). VI was associated inversely with suicidal thinking (r = –0.61 with all subjects and r = –0.73 with bipolar disorder subjects; both p<0.0001) and distinguished patients with bipolar versus unipolar major depression with a sensitivity of 91.7% and a specificity of 79.2%. VI may be a useful biomarker of characteristic features of major depression, contribute to differentiating bipolar and unipolar depression, and help to detect risk of suicide. An objective biomarker of suicide-risk could be advantageous when patients are unwilling or unable to share suicidal thinking with clinicians.
Published Version: doi:10.1371/journal.pone.0038761
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373552/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10423818
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters