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dc.contributor.authorSohur, Usharbudh Shivraj
dc.contributor.authorPadmanabhan, Hari
dc.contributor.authorKotchetkov, Ivan S.
dc.contributor.authorMenezes, Joao R.L.
dc.contributor.authorMacklis, Jeffrey Daniel
dc.date.accessioned2013-03-18T13:27:09Z
dc.date.issued2013-03-18
dc.identifier.citationSohur, Usharbudh Shivraj, Hari Padmanabhan, Ivan S. Kotchetkov, Joao R.L. Menezes, and Jeffrey Daniel Macklis. Forthcoming. Anatomic and molecular development of corticostriatal projection neurons in mice. Cerebral Cortex.en_US
dc.identifier.issn1047-3211en_US
dc.identifier.issn1460-2199en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10423837
dc.description.abstractCorticostriatal projection neurons (CStrPN) project from the neocortex to ipsilateral and contralateral striata to control and coordinate motor programs and movement. They are clinically important as the predominant cortical population that degenerates in Huntington's disease and corticobasal ganglionic degeneration, and their injury contributes to multiple forms of cerebral palsy. Together with their well-studied functions in motor control, these clinical connections make them a functionally, behaviorally, and clinically important population of neocortical neurons. Little is known about their development. “Intratelencephalic” CStrPN \((CStrPN_i)\), projecting to the contralateral striatum, with their axons fully within the telencephalon (intratelencephalic), are a major population of CStrPN. \(CStrPN_i\) are of particular interest developmentally because they share hodological and axon guidance characteristics of both callosal projection neurons (CPN) and corticofugal projection neurons (CFuPN); \(CStrPN_i\) send axons contralaterally before descending into the contralateral striatum. The relationship of \(CStrPN_i\) development to that of broader CPN and CFuPN populations remains unclear; evidence suggests that \(CStrPN_i\) might be evolutionary “hybrids” between CFuPN and deep layer CPN—in a sense “chimeric” with both callosal and corticofugal features. Here, we investigated the development of \(CStrPN_i\) in mice—their birth, maturation, projections, and expression of molecular developmental controls over projection neuron subtype identity.en_US
dc.description.sponsorshipStem Cell and Regenerative Biologyen_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofdoi:10.1093/cercor/bhs342en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/23118198en_US
dash.licenseOAP
dc.subjectcorticostriatal projection neuronsen_US
dc.subjectcallosal projection neuronsen_US
dc.subjectcorticofugal projection neuronsen_US
dc.subjectneocortexen_US
dc.subjectstriatumen_US
dc.titleAnatomic and Molecular Development of Corticostriatal Projection Neurons in Miceen_US
dc.typeJournal Articleen_US
dc.description.versionAuthor's Originalen_US
dc.relation.journalCerebral Cortexen_US
dash.depositing.authorMacklis, Jeffrey Daniel
dc.date.available2013-03-18T13:27:09Z
dc.identifier.doi10.1093/cercor/bhs342*
dash.contributor.affiliatedSohur, Usharbudh
dash.contributor.affiliatedPadmanabhan, Hari
dash.contributor.affiliatedMacklis, Jeffrey


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