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dc.contributor.authorRice, Megan Siobhan
dc.contributor.authorMurphy, Megan A.
dc.contributor.authorTworoger, Shelley Slate
dc.date.accessioned2013-03-18T17:36:47Z
dc.date.issued2012
dc.identifier.citationRice, Megan S, Megan A Murphy, and Shelley S Tworoger. 2012. Tubal ligation, hysterectomy and ovarian cancer: a meta-analysis. Journal of Ovarian Research 5: 13.en_US
dc.identifier.issn1757-2215en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10436234
dc.description.abstractPurpose: The purpose of this meta-analysis was to determine the strength of the association between gynecologic surgeries, tubal ligation and hysterectomy, and ovarian cancer. Methods: We searched the PubMed, Web of Science, and Embase databases for all English-language articles dated between 1969 through March 2011 using the keywords "ovarian cancer" and "tubal ligation" or "tubal sterilization" or "hysterectomy." We identified 30 studies on tubal ligation and 24 studies on hysterectomy that provided relative risks for ovarian cancer and a p-value or 95% confidence interval (CI) to include in the meta-analysis. Summary RRs and 95% CIs were calculated using a random-effects model. Results: The summary RR for women with vs. without tubal ligation was 0.70 (95%CI: 0.64, 0.75). Similarly, the summary RR for women with vs. without hysterectomy was 0.74 (95%CI: 0.65, 0.84). Simple hysterectomy and hysterectomy with unilateral oophorectomy were associated with a similar decrease in risk (summery RR = 0.62, 95%CI: 0.49-0.79 and 0.60, 95%CI: 0.47-0.78, respectively). In secondary analyses, the association between tubal ligation and ovarian cancer risk was stronger for endometrioid tumors (summary RR = 0.45, 95%CI: 0.33, 0.61) compared to serous tumors. Conclusion: Observational epidemiologic evidence strongly supports that tubal ligation and hysterectomy are associated with a decrease in the risk of ovarian cancer, by approximately 26-30%. Additional research is needed to determine whether the association between tubal ligation and hysterectomy on ovarian cancer risk differs by individual, surgical, and tumor characteristics.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1757-2215-5-13en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386864/pdf/en_US
dash.licenseLAA
dc.subjectOvarian neoplasmsen_US
dc.subjectSterilizationen_US
dc.subjectTubalen_US
dc.subjectHysterectomyen_US
dc.titleTubal Ligation, Hysterectomy and Ovarian Cancer: A Meta-Analysisen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Ovarian Researchen_US
dash.depositing.authorTworoger, Shelley Slate
dc.date.available2013-03-18T17:36:47Z
dc.identifier.doi10.1186/1757-2215-5-13*
dash.contributor.affiliatedRice, Megan
dash.contributor.affiliatedTworoger, Shelley


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