In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases

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In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases

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Title: In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases
Author: Zhang, Yiyun; Yeh, Jing-Ruey Joanna

Note: Order does not necessarily reflect citation order of authors.

Citation: Zhang, Yiyun, and J.-R. Joanna Yeh. 2012. In vivo chemical screening for modulators of hematopoiesis and hematological diseases. Advances in Hematology 2012.
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Abstract: In vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may be pharmacologically modulated. Both high-throughput chemical screening and facile detection of blood-cell-related phenotypes are feasible in embryonic/larval zebrafish. Two recent studies utilizing phenotypic chemical screens in zebrafish have identified several compounds that promote hematopoietic stem cell formation and reverse the hematopoietic phenotypes of a leukemia oncogene, respectively. These studies illustrate efficient drug discovery processes in zebrafish and reveal novel biological roles of prostaglandin E2 in hematopoietic and leukemia stem cells. Furthermore, the compounds discovered in zebrafish screens have become promising therapeutic candidates against leukemia and included in a clinical trial for enhancing hematopoietic stem cells during hematopoietic cell transplantation.
Published Version: doi:10.1155/2012/851674
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385708/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436304
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