Viral Perturbations of Host Networks Reflect Disease Etiology

DSpace/Manakin Repository

Viral Perturbations of Host Networks Reflect Disease Etiology

Citable link to this page

 

 
Title: Viral Perturbations of Host Networks Reflect Disease Etiology
Author: Gulbahce, Natali; Dricot, Amélie; Byrdsong, Danielle; Franchi, Rachel; Lee, Deok-Sun; Rozenblatt-Rosen, Orit; Mar, Jessica C.; Baldwin, Amy; Santhanam, Balaji; Braun, Pascal; Simonis, Nicolas; Huh, Kyung-Won; Hellner, Karin; Grace, Miranda; Rubio, Renee; Roecklein-Canfield, Jennifer; Münger, Karl; Barabási, Albert-László; Yan, Han; Padi, Megha; Calderwood, Michael A; Chen, Alyce Aura; Marto, Jarrod; Christakis, Nicholas Alexander; Kieff, Elliott D.; Roth, Frederick Phillip; DeCaprio, James A.; Cusick, Michael; Quackenbush, John; Hill, David E.; Vidal, Marc; Zhao, Bo

Note: Order does not necessarily reflect citation order of authors.

Citation: Gulbahce, Natali, Han Yan, Amélie Dricot, Megha Padi, Danielle Byrdsong, Rachel Franchi, Deok-Sun Lee, Orit Rozenblatt-Rosen, Jessica C. Mar, Michael A. Calderwood, Amy Baldwin, Bo Zhao, Balaji Santhanam, Pascal Braun, Nicolas Simonis, Kyung-Won Huh, Karin Hellner, Miranda Grace, Alyce Chen, Renee Rubio, Jarrod A. Marto, Nicholas A. Christakis, Elliott Kieff, Frederick P. Roth, Jennifer Roecklein-Canfield, James A. DeCaprio, Michael E. Cusick, John Quackenbush, David E. Hill, Karl Münger, Marc Vidal, and Albert-László Barabási. 2012. Viral perturbations of host networks reflect disease etiology. PLoS Computational Biology 8(6).
Full Text & Related Files:
Abstract: Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), we find that host targets of viral proteins reside in network proximity to products of disease susceptibility genes. Expression changes in virally implicated disease tissues and comorbidity patterns cluster significantly in the network vicinity of viral targets. The topological proximity found between cellular targets of viral proteins and disease genes was exploited to uncover a novel pathway linking HPV to Fanconi anemia.
Published Version: doi:10.1371/journal.pcbi.1002531
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386155/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10436315
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters