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dc.contributor.authorLin, Jennifer H.
dc.contributor.authorGunter, Marc J.
dc.contributor.authorManson, JoAnn Elisabeth
dc.contributor.authorRexrode, Kathryn Marian
dc.contributor.authorCook, Nancy Romanowicz
dc.contributor.authorKraft, Peter
dc.contributor.authorCochrane, Barbara B.
dc.contributor.authorChlebowski, Rowan T.
dc.contributor.authorHo, Gloria Y. F.
dc.contributor.authorZhang, Shumin
dc.date.accessioned2013-03-18T19:22:07Z
dc.date.issued2012
dc.identifier.citationLin, Jennifer H., Marc J. Gunter, JoAnn E. Manson, Kathryn M. Rexrode, Nancy R. Cook, Peter Kraft, Barbara B. Cochrane, Rowan T. Chlebowski, Gloria Y. F. Ho, and Shumin M. Zhang. 2012. The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women. PLoS ONE 7(7).en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10436324
dc.description.abstractBackground: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production may influence HGF levels. We examined the association between the CYP19A1 gene variants and plasma HGF concentrations. Design We evaluated 45 common and putative functional variants of CYP19A1 and circulating levels of HGF among 260 postmenopausal women who later developed colorectal cancer from the Women's Health Initiative Observational Cohort. As the distribution of HGF levels was highly skewed, we transformed HGF concentrations for all women into a log-, ranked-, or normal score-scale value. Multiple linear regression with adjustment for age was used to evaluate the associations. Results: We observed an association between the rs7172156, rs1008805, rs6493494, rs749292, and rs11636639 variants and HGF levels in ranked and normal score scales (corrected p values ≤0.02), although the association of these 5 SNPs with log-scale HGF was not significant (corrected p values ≥0.16). The associations remained unchanged after additional adjustment for hormone therapy use and estradiol levels. These 5 SNPs, which were in linkage disequilibrium (pairwise D′≥97%, r2≥56%), constituted a block with 2 common haplotypes accounting for 82% frequency. The most common haplotype, TCCCA, was associated with lower ranked- or normal score-transformed HGF levels (corrected p values ≤0.001), whereas the second most common haplotype, CTTCA, was associated with higher ranked- or normal score-transformed HGF levels (corrected p values ≤0.02). Conclusion: Our findings of a potential association between the CYP19A1 variants and circulating HGF levels warrant confirmation in studies with larger sample size.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0042079en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405042/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectComputational Biologyen_US
dc.subjectPopulation Geneticsen_US
dc.subjectGenetic Polymorphismen_US
dc.subjectEvolutionary Biologyen_US
dc.subjectGeneticsen_US
dc.subjectPopulation Biologyen_US
dc.subjectMedicineen_US
dc.subjectEpidemiologyen_US
dc.subjectCancer Epidemiologyen_US
dc.subjectCardiovascular Disease Epidemiologyen_US
dc.subjectGenetic Epidemiologyen_US
dc.subjectNon-Clinical Medicineen_US
dc.subjectHealth Care Policyen_US
dc.subjectHealth Risk Analysisen_US
dc.subjectWomen's Healthen_US
dc.titleThe Aromatase Gene (CYP19A1) Variants and Circulating Hepatocyte Growth Factor in Postmenopausal Womenen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorZhang, Shumin
dc.date.available2013-03-18T19:22:07Z
dc.identifier.doi10.1371/journal.pone.0042079*
dash.contributor.affiliatedZhang, Shumin
dash.contributor.affiliatedCook, Nancy
dash.contributor.affiliatedRexrode, Kathryn
dash.contributor.affiliatedManson, JoAnn


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