Show simple item record

dc.contributor.authorBowers, Katherine
dc.contributor.authorYeung, Edwina
dc.contributor.authorWilliams, Michelle A
dc.contributor.authorQi, Lu
dc.contributor.authorTobias, Deirdre Kay
dc.contributor.authorHu, Frank B.
dc.contributor.authorZhang, Cuilin
dc.date.accessioned2013-03-18T19:31:43Z
dc.date.issued2011
dc.identifier.citationBowers, Katherine, Edwina Yeung, Michelle A. Williams, Lu Qi, Deirdre K. Tobias, Frank B. Hu, and Cuilin Zhang. 2011. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care 34(7): 1557-1563.en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10436336
dc.description.abstractOBJECTIVE It is important to identify modifiable factors that may lower gestational diabetes mellitus (GDM) risk. Dietary iron is of particular interest given that iron is a strong prooxidant, and high body iron levels can damage pancreatic β-cell function and impair glucose metabolism. The current study is to determine if prepregnancy dietary and supplemental iron intakes are associated with the risk of GDM. RESEARCH DESIGN AND METHODS A prospective study was conducted among 13,475 women who reported a singleton pregnancy between 1991 and 2001 in the Nurses’ Health Study II. A total of 867 incident GDM cases were reported. Pooled logistic regression was used to estimate the relative risk (RR) of GDM by quintiles of iron intake controlling for dietary and nondietary risk factors. RESULTS Dietary heme iron intake was positively and significantly associated with GDM risk. After adjusting for age, BMI, and other risk factors, RRs (95% CIs) across increasing quintiles of heme iron were 1.0 (reference), 1.11 (0.87–1.43), 1.31 (1.03–1.68), 1.51 (1.17–1.93), and 1.58 (1.21–2.08), respectively (P for linear trend 0.0001). The multivariate adjusted RR for GDM associated with every 0.5-mg per day of increase in intake was 1.22 (1.10–1.36). No significant associations were observed between total dietary, nonheme, or supplemental iron intake and GDM risk. CONCLUSIONS These findings suggest that higher prepregnancy intake of dietary heme iron is associated with an increased GDM risk.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi:10.2337/dc11-0134en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120196/pdf/en_US
dash.licenseLAA
dc.subjectEpidemiology/Health Services Researchen_US
dc.titleA Prospective Study of Prepregnancy Dietary Iron Intake and Risk for Gestational Diabetes Mellitusen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetes Careen_US
dash.depositing.authorHu, Frank B.
dc.date.available2013-03-18T19:31:43Z
dc.identifier.doi10.2337/dc11-0134*
dash.contributor.affiliatedTobias, Deirdre
dash.contributor.affiliatedWilliams, Michelle
dash.contributor.affiliatedQi, Lu
dash.contributor.affiliatedHu, Frank


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record