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dc.contributor.authorSteinhauser, Matthew L.
dc.contributor.authorLee, Richard Theodore
dc.date.accessioned2013-03-18T19:39:11Z
dc.date.issued2011
dc.identifier.citationSteinhauser, Matthew L, and Richard T Lee. 2011. Regeneration of the heart. EMBO Molecular Medicine 3(12): 701-712.en_US
dc.identifier.issn1757-4676en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10436345
dc.description.abstractThe death of cardiac myocytes diminishes the heart's pump function and is a major cause of heart failure, one of the dominant causes of death worldwide. Other than transplantation, there are no therapies that directly address the loss of cardiac myocytes, which explains the current excitement in cardiac regeneration. The field is evolving in two important directions. First, although endogenous mammalian cardiac regeneration clearly seems to decline rapidly after birth, it may still persist in adulthood. The careful elucidation of the cellular and molecular mechanisms of endogenous heart regeneration may therefore provide an opportunity for developing therapeutic interventions that amplify this process. Second, recent breakthroughs have enabled reprogramming of cells that were apparently terminally differentiated, either by dedifferentiation into pluripotent stem cells or by transdifferentiation into cardiac myocytes. These achievements challenge our conceptions of what is possible in terms of heart regeneration. In this review, we discuss the current status of research on cardiac regeneration, with a focus on the challenges that hold back therapeutic development.en_US
dc.language.isoen_USen_US
dc.publisherWILEY-VCH Verlagen_US
dc.relation.isversionofdoi:10.1002/emmm.201100175en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377117/pdf/en_US
dash.licenseLAA
dc.titleRegeneration of the hearten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEMBO Molecular Medicineen_US
dash.depositing.authorSteinhauser, Matthew L.
dc.date.available2013-03-18T19:39:11Z
dc.identifier.doi10.1002/emmm.201100175*
dash.contributor.affiliatedSteinhauser, Matthew
dash.contributor.affiliatedLee, Richard


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