# Type 2 Diabetes and the Risk of Renal Cell Cancer in Women

 Title: Type 2 Diabetes and the Risk of Renal Cell Cancer in Women Author: Joh, Hee-Kyung; Willett, Walter C.; Cho, Eunyoung Note: Order does not necessarily reflect citation order of authors. Citation: Joh, Hee-Kyung, Walter C. Willett, and Eunyoung Cho. 2011. Type 2 diabetes and the risk of renal cell cancer in women. Diabetes Care 34(7): 1552-1556. Full Text & Related Files: 3120193.pdf (585.2Kb; PDF) Abstract: Objective: Type 2 diabetes is associated with increased risks of several types of cancer; however, its relationship to renal cell cancer remains unclear. Research Design and Methods: A total of 118,177 women aged 30 to 55 years at baseline (1976) were followed up through 2008 in the Nurses’ Health Study. Self-reports of physician-diagnosed diabetes were collected at baseline and updated biennially. Hazard ratios (HRs) were calculated using Cox proportional hazards models with adjustment for age, BMI, hypertension, smoking, and parity. Results: During 32 years of follow-up (3,531,170 person-years), 16,819 cases of type 2 diabetes and 330 cases of pathology-confirmed incident renal cell cancer were documented. After multivariate adjustment, type 2 diabetes was significantly associated with an increased risk of renal cell cancer (HR 1.60 [95% CI 1.19–2.17]). These associations were consistent across different strata of BMI, smoking, and hypertension ($$P_{interaction} \geq 0.32$$). The risk of renal cell cancer increased with an increasing number of comorbidities, including obesity, hypertension, and type 2 diabetes ($$P_{trend} < 0.001$$). When compared with women without any comorbidity, women who had all three conditions had a HR of 4.13 (2.76–6.18) for renal cell cancer. Conclusions: Type 2 diabetes is independently associated with an increased risk of renal cell cancer in women. In addition, comorbidity of obesity, hypertension, and type 2 diabetes substantially elevates the risk of renal cell cancer. Published Version: doi:10.2337/dc11-0132 Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120193/pdf/ Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10445604 Downloads of this work: