The Uncoordinated-5 Homolog B Receptor Affects Hepatic Ischemia Reperfusion Injury

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The Uncoordinated-5 Homolog B Receptor Affects Hepatic Ischemia Reperfusion Injury

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Title: The Uncoordinated-5 Homolog B Receptor Affects Hepatic Ischemia Reperfusion Injury
Author: König, Klemens; Köhler, David; Granja, Tiago; Jennewein, Carla; Tran, Nguyen; Kröhnert, Friedemann; Rosenberger, Peter; Mirakaj, Valbona

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Citation: König, Klemens, David Köhler, Tiago Granja, Carla Jennewein, Nguyen Tran, Valbona Mirakaj, Friedemann Kröhnert, and Peter Rosenberger. 2012. The Uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury. PLoS ONE 7(7): e41085.
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Abstract: Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of UNC5B during an acute inflammatory response we investigated the role of UNC5B on acute hepatic IRI. We report here that UNC5B^{+/−} mice display reduced hepatic IRI and neutrophil (PMN) infiltration compared to WT controls. This correlated with serum levels of lactate dehydrogenase (LDH), aspartate- (AST) and alanine- (ALT) aminotransferase, the presence of PMN within ischemic hepatic tissue, and serum levels of inflammatory cytokines. Moreover, injection of an anti-UNC5B antibody resulted in a significant reduction of hepatic IR injury. This was associated with reduced parameters of liver injury (LDH, ALT, AST) and accumulation of PMN within the injured hepatic tissue. In conclusion our studies demonstrate a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future.
Published Version: doi:10.1371/journal.pone.0041085
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405071/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10445631
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