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dc.contributor.authorPike, Marilyn Cecile
dc.contributor.authorKelley, Lexy
dc.date.accessioned2013-03-19T19:01:47Z
dc.date.issued2012
dc.identifier.citationPike, Marilyn C., and Lexy Kelley. 2012. Data quality challenges in systemic lupus erythematosus trials: how can this be optimized? Current Rheumatology Reports 14(4): 324-333.en_US
dc.identifier.issn1523-3774en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10445642
dc.description.abstractMajor scientific advances in basic science, pharmacology, and translational medicine have allowed the discovery of new molecular targets whose manipulation by new chemical entities has led to treatments for inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Development of new agents for systemic lupus erythematosus (SLE) has lagged, however, because the protean manifestations of SLE present challenges for measuring therapeutic effects in a consistent manner. Composite end points combining several Disease Activity Indices (DAIs) are being used in ongoing global studies, but the uniform application of these complex DAIs across large numbers of clinical sites has proven difficult. We describe herein approaches that are being utilized to facilitate collection, review, and analysis of the clinical measures utilizing independent central adjudication committees.en_US
dc.language.isoen_USen_US
dc.publisherCurrent Science Inc.en_US
dc.relation.isversionofdoi:10.1007/s11926-012-0261-7en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387490/pdf/en_US
dash.licenseLAA
dc.titleData Quality Challenges in Systemic Lupus Erythematosus Trials: How Can This Be Optimized?en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCurrent Rheumatology Reportsen_US
dash.depositing.authorPike, Marilyn Cecile
dc.date.available2013-03-19T19:01:47Z
dc.identifier.doi10.1007/s11926-012-0261-7*
dash.contributor.affiliatedPike, Marilyn Cecile


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