Histocompatibility and Hematopoietic Transplantation in the Zebrafish

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Histocompatibility and Hematopoietic Transplantation in the Zebrafish

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Title: Histocompatibility and Hematopoietic Transplantation in the Zebrafish
Author: de Jong, Jill L. O.; Zon, Leonard Ira

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Citation: de Jong, Jill L. O., and Leonard I. Zon. 2012. Histocompatibility and hematopoietic transplantation in the zebrafish. Advances in Hematology 2012:282318.
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Abstract: The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. The genetic program that regulates the development and differentiation of hematopoietic cells is highly conserved. Hematopoietic stem cells (HSCs) are the source of all the blood cells needed by an organism during its lifetime. Identifying an HSC requires a functional assay, namely, a transplantation assay consisting of multilineage engraftment of a recipient and subsequent serial transplant recipients. In the past decade, several types of hematopoietic transplant assays have been developed in the zebrafish. An understanding of the major histocompatibility complex (MHC) genes in the zebrafish has lagged behind transplantation experiments, limiting the ability to perform unbiased competitive transplantation assays. This paper summarizes the different hematopoietic transplantation experiments performed in the zebrafish, both with and without immunologic matching, and discusses future directions for this powerful experimental model of human blood diseases.
Published Version: doi:10.1155/2012/282318
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388487/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10448842
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