Potential for false positive HIV test results with the serial rapid HIV testing algorithm

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Potential for false positive HIV test results with the serial rapid HIV testing algorithm

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Title: Potential for false positive HIV test results with the serial rapid HIV testing algorithm
Author: Baveewo, Steven; Kamya, Moses R; Mayanja-Kizza, Harriet; Fatch, Robin; Coates, Thomas; Hahn, Judith A; Wanyenze, Rhoda K; Bangsberg, David Roy

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Citation: Baveewo, Steven, Moses R Kamya, Harriet Mayanja-Kizza, Robin Fatch, David R Bangsberg, Thomas Coates, Judith A Hahn, and Rhoda K Wanyenze. 2012. Potential for false positive HIV test results with the serial rapid hiv testing algorithm. BMC Research Notes 5:154.
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Abstract: Background: Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results: Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion: Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals.
Published Version: doi:10.1186/1756-0500-5-154
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392728/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10456101
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