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dc.contributor.authorLi, Shengping
dc.contributor.authorQian, Ji
dc.contributor.authorZhao, Wanting
dc.contributor.authorDai, Juncheng
dc.contributor.authorBei, Jin-Xin
dc.contributor.authorFoo, Jia Nee
dc.contributor.authorMcLaren, Paul J.
dc.contributor.authorLi, Zhiqiang
dc.contributor.authorYang, Jingmin
dc.contributor.authorShen, Feng
dc.contributor.authorYang, Jiamei
dc.contributor.authorLi, Shuhong
dc.contributor.authorPan, Shandong
dc.contributor.authorLi, Wenjin
dc.contributor.authorZhai, Xiangjun
dc.contributor.authorZhou, Boping
dc.contributor.authorShi, Lehua
dc.contributor.authorChen, Xinchun
dc.contributor.authorChu, Minjie
dc.contributor.authorYan, Yiqun
dc.contributor.authorCheng, Shuqun
dc.contributor.authorShen, Jiawei
dc.contributor.authorJia, Weihua
dc.contributor.authorLiu, Jibin
dc.contributor.authorYang, Jiahe
dc.contributor.authorWen, Zujia
dc.contributor.authorLi, Aijun
dc.contributor.authorZhang, Guoliang
dc.contributor.authorLuo, Xianrong
dc.contributor.authorQin, Hongbo
dc.contributor.authorChen, Minshan
dc.contributor.authorLin, Dongxin
dc.contributor.authorShen, Hongbing
dc.contributor.authorWang, Hongyang
dc.contributor.authorZeng, Yi-Xin
dc.contributor.authorWu, Mengchao
dc.contributor.authorHu, Zhibin
dc.contributor.authorShi, Yongyong
dc.contributor.authorLiu, Jianjun
dc.contributor.authorZhou, Weiping
dc.contributor.authorYang, Yuan
dc.contributor.authorLiu, Li
dc.contributor.authorWang, Yi
dc.contributor.authorWang, Jun
dc.contributor.authorZhang, Ying
dc.contributor.authorWang, Hua
dc.contributor.authorJin, Li
dc.contributor.authorHe, Lin
dc.contributor.authorde Bakker, Paul I. Wen
dc.date.accessioned2013-03-21T20:52:25Z
dc.date.issued2012
dc.identifier.citationLi, Shengping, Ji Qian, Yuan Yang, Wanting Zhao, Juncheng Dai, Jin-Xin Bei, Jia Nee Foo, Paul J. McLaren, Zhiqiang Li, Jingmin Yang, Feng Shen, Li Liu, Jiamei Yang, Shuhong Li, Shandong Pan, Yi Wang, Wenjin Li, Xiangjun Zhai, Boping Zhou, Lehua Shi, Xinchun Chen, Minjie Chu, Yiqun Yan, Jun Wang, Shuqun Cheng, Jiawei Shen, Weihua Jia, Jibin Liu, Jiahe Yang, Zujia Wen, Aijun Li, Ying Zhang, Guoliang Zhang, Xianrong Luo, Hongbo Qin, Minshan Chen, Hua Wang, Li Jin, Dongxin Lin, Hongbing Shen, Lin He, Paul I. W. de Bakker, Hongyang Wang, Yi-Xin Zeng, Mengchao Wu, Zhibin Hu, Yongyong Shi, Jianjun Liu, and Weiping Zhou. 2012. Gwas identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genetics 8(7): e1002791.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10456187
dc.description.abstractGenome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel susceptibility loci associated with HBV–related HCC and replicate the previously reported association, we performed a large three-stage GWAS in the Han Chinese population. 523,663 autosomal SNPs in 1,538 HBV–positive HCC patients and 1,465 chronic HBV carriers were genotyped for the discovery stage. Top candidate SNPs were genotyped in the initial validation samples of 2,112 HBV–positive HCC cases and 2,208 HBV carriers and then in the second validation samples of 1,021 cases and 1,491 HBV carriers. We discovered two novel associations at rs9272105 (HLA-DQA1/DRB1) on 6p21.32 (OR = 1.30, P = 1.13×\(10^{−19}\)) and rs455804 (GRIK1) on 21q21.3 (OR = 0.84, P = 1.86×\(10^{−8}\)), which were further replicated in the fourth independent sample of 1,298 cases and 1,026 controls (rs9272105: OR = 1.25, P = 1.71×\(10^{−4}\); rs455804: OR = 0.84, P = 6.92×\(10^{−3}\)). We also revealed the associations of HLA-DRB1*0405 and 0901*0602, which could partially account for the association at rs9272105. The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV–related HCC, suggesting the involvement of glutamate signaling in the development of HBV–related HCC.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1002791en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395595/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectGeneticsen_US
dc.subjectCancer Geneticsen_US
dc.subjectGenome-Wide Association Studiesen_US
dc.titleGWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorde Bakker, Paul I. Wen
dc.date.available2013-03-21T20:52:25Z
dc.identifier.doi10.1371/journal.pgen.1002791*
dash.authorsorderedfalse
dash.contributor.affiliatedde Bakker, Paul


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