Environmental conditioning in the control of macrophage thrombospondin-1 production
Fordham, Jezrom B.
Morwood, Sarah R.
Schewitz-Bowers, Lauren P.
Copland, David A.
Dick, Andrew D.
Nicholson, Lindsay B.
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CitationFordham, Jezrom B., Jing Hua, Sarah R. Morwood, Lauren P. Schewitz-Bowers, David A. Copland, Andrew D. Dick, and Lindsay B. Nicholson. 2012. Environmental conditioning in the control of macrophage thrombospondin-1 production. Scientific Reports 2:512.
AbstractThrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune infiltrate. Macrophages are a source of TSP-1, which they produce in response to TLR4 mediated signals. Their production of TSP-1 is regulated by environmental signals that establish a threshold for the level of protein secretion that can be induced by LPS stimulation. Th1 and Th2 cytokines raise this threshold which leads to less TSP-1 production, while signals that promote the generation of regulatory macrophages lower it. TSP-1 plays no direct role in the regulation of its own secretion. In vivo in uveitis, in the presence of TLR-4 ligands, TSP-1 is initially produced by recruited macrophages but this decreases in the presence of inflammatory cytokines. The adaptive immune system therefore plays a dominant role in regulating TSP-1 production in the target organ during acute inflammation.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10464971
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