dc.contributor.author | Fordham, Jezrom B. | |
dc.contributor.author | Hua, Jing | |
dc.contributor.author | Morwood, Sarah R. | |
dc.contributor.author | Schewitz-Bowers, Lauren P. | |
dc.contributor.author | Copland, David A. | |
dc.contributor.author | Dick, Andrew D. | |
dc.contributor.author | Nicholson, Lindsay B. | |
dc.date.accessioned | 2013-03-26T15:47:27Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Fordham, Jezrom B., Jing Hua, Sarah R. Morwood, Lauren P. Schewitz-Bowers, David A. Copland, Andrew D. Dick, and Lindsay B. Nicholson. 2012. Environmental conditioning in the control of macrophage thrombospondin-1 production. Scientific Reports 2:512. | en_US |
dc.identifier.issn | 2045-2322 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10464971 | |
dc.description.abstract | Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune infiltrate. Macrophages are a source of TSP-1, which they produce in response to TLR4 mediated signals. Their production of TSP-1 is regulated by environmental signals that establish a threshold for the level of protein secretion that can be induced by LPS stimulation. Th1 and Th2 cytokines raise this threshold which leads to less TSP-1 production, while signals that promote the generation of regulatory macrophages lower it. TSP-1 plays no direct role in the regulation of its own secretion. In vivo in uveitis, in the presence of TLR-4 ligands, TSP-1 is initially produced by recruited macrophages but this decreases in the presence of inflammatory cytokines. The adaptive immune system therefore plays a dominant role in regulating TSP-1 production in the target organ during acute inflammation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | doi:10.1038/srep00512 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397322/pdf/ | en_US |
dash.license | LAA | |
dc.title | Environmental conditioning in the control of macrophage thrombospondin-1 production | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Scientific Reports | en_US |
dash.depositing.author | Hua, Jing | |
dc.date.available | 2013-03-26T15:47:27Z | |
dc.identifier.doi | 10.1038/srep00512 | * |
dash.contributor.affiliated | Hua, Jing | |