Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function

DSpace/Manakin Repository

Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function

Citable link to this page

 

 
Title: Long-Term Prognostic Importance of Diabetes After a Myocardial Infarction Depends on Left Ventricular Systolic Function
Author: Andersson, Charlotte; Gislason, Gunnar H.; Mérie, Charlotte; Mogensen, Ulrik M.; Torp-Pedersen, Christian; Køber, Lars; Solomon, Scott David

Note: Order does not necessarily reflect citation order of authors.

Citation: Andersson, Charlotte, Gunnar H. Gislason, Charlotte Mérie, Ulrik M. Mogensen, Scott D. Solomon, Christian Torp-Pedersen, and Lars Køber. 2011. Long-term prognostic importance of diabetes after a myocardial infarction depends on left ventricular systolic function. Diabetes Care 34(8): 1788-1790.
Full Text & Related Files:
Abstract: Objective: This study was performed to understand how left ventricular function modulates the prognostic importance of diabetes after myocardial infarction (MI). Research Design and Methods: Consecutively hospitalized MI patients screened for three clinical trials were followed for a median of 7 years. Multivariable Cox regression models were used to assess the risk of mortality associated with diabetes, and the importance of diabetes was examined independently within defined left ventricular ejection fraction (LVEF) subgroups. Results: A total of 16,912 patients were included; 1,819 (11%) had diabetes. Diabetes and 15% unit depression in LVEF were of similar prognostic importance: hazard ratios (HRs) were 1.45 (95% CI 1.37–1.54) and 1.41 (1.37–1.45) for diabetes and LVEF depression, respectively. LVEF modified the outcomes associated with diabetes, with HRs being 1.29 (1.19–1.40) and 1.61 (1.49–1.74) in patients with LVEF <40% and LVEF ≥40%, respectively (P = 0.03). Conclusions: Patients within the higher LVEF categories have a greater mortality risk attributable to diabetes than patients within the lower LVEF categories.
Published Version: doi:10.2337/dc11-0154
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142062/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10465032
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters