Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
Citation
Tan, K. M., M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter. 2012. Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance. Biomedical Optics Express 3(8): 1947-1954.Abstract
Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the catheter sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409712/pdf/Terms of Use
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