Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance
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CitationTan, K. M., M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter. 2012. Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance. Biomedical Optics Express 3(8): 1947-1954.
AbstractTransbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the catheter sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10465994
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